4-TRIFLUOROMETHYL-BENZAMIDINE HCL Chemical Properties

Melting point:

158-161℃

storage temp. 

Inert atmosphere,Room Temperature

form 

powder to crystal

color 

White to Almost white

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38-43

Safety Statements 

26-37/39-36/37

HS Code 

2925290090

4-TRIFLUOROMETHYL-BENZAMIDINE HCL Usage And Synthesis

Uses

4-Trifluoromethylbenzamide hydrochloride is used as a pharmaceutical synthesis intermediate.

Synthesis

4-(Trifluoromethyl)benzonitrile (15g, Avocado 14514) was used as raw material, which was dissolved in anhydrous methanol (90 ml) and sodium methanolate (0.50 g) was added. The reaction mixture was stirred at room temperature for 4 days. Subsequently, ammonium chloride (4.7 g) was added to the reaction system and stirring was continued for 24 hours. Upon completion of the reaction, the solvent was removed by rotary evaporator and the white solid residue obtained was ground with ether, filtered and dried to afford the target product 4-(trifluoromethyl)benzamidine hydrochloride as a white solid (14.2 g, 72% yield). Mass spectrometry analysis showed a molecular ion peak of 188 [M]+.

References

[1] Patent: US2003/69276, 2003, A1
[2] Journal of the American Chemical Society, 1985, vol. 107, # 9, p. 2743 - 2748
[3] Journal of Medicinal Chemistry, 1990, vol. 33, # 4, p. 1230 - 1241
[4] Patent: US6121202, 2000, A
[5] Patent: US2012/165343, 2012, A1. Location in patent: Page/Page column 55

4-TRIFLUOROMETHYL-BENZAMIDINE HCL(38980-96-0)Related Product Information

• Formamidine hydrochloride
• 2-(4-(trifluoromethyl)phenyl)acetaldehyde
• 4-(Trifluoromethyl)indoline
• C-(4-Trifluoromethyl-pyridin-2-yl)-methylamine
• 4-(TRIFLUOROMETHYL)-1H-INDOLE
• 4-(TRIFLUOROMETHYL)QUINOLINE
• Ethylbenzene
• Trifluoro-p-tolunitrile
• Benzotrifluoride
• Benzamidine hydrochloride
• 2,2′-Azobis(2-methylpropionamidine) dihydrochloride
• SeMiaMitraz chloride
• 3-Aminomethylphenylboronic acid hydrochloride
• Dimethyl-p-phenylenediamine hydrochloride
• 3-TRIFLUOROMETHYL-BENZAMIDINE HCL
• 4-TRIFLUOROMETHYL-BENZAMIDINE
• 2-CHLORO-5-TRIFLUOROMETHYL-BENZAMIDINE HCL
• 2-TRIFLUOROMETHYL-BENZAMIDINE HCL