Tolperisone hydrochloride Chemical Properties

Melting point:

181-183°C

storage temp. 

room temp

solubility 

H2O: >20mg/mL

form 

solid

color 

white

PH

pH(50g/l, 25℃) : 4.5～5.5

Water Solubility 

almost transparency

Merck 

14,9522

CAS DataBase Reference

3644-61-9(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xn,Xi

Risk Statements 

20/21/22-52/53-36/37/38

Safety Statements 

26-36-45-61-36/37-37/39

WGK Germany 

3

RTECS 

UH1575500

Toxicity

LD50 s.c. in mice: 620 mg/kg (Porszasz, 1961)

Tolperisone hydrochloride Usage And Synthesis

Chemical Properties

White Solid

Originator

Tolperisone hydrochloride,Shanghai Abochem Chemical Co.

Uses

Tolperisone hydrochloride can be used as a muscle relaxant.

Definition

ChEBI: Tolperisone hydrochloride is an aromatic ketone.

Manufacturing Process

To 1-(4-methylphenyl)-3-(1-piperidinyl)-1-propanol in chloroform was added an excess of thionyl chloride and the reaction mixture refluxed until completed. It was then taken to dryness under reduced pressure and the residue crystallized by dissolving in hot alcohol and diluting with ethyl acetate. An aqueous solution of the obtained N-[3-chloro-3-(p-tolyl)propyl]piperidine hydrochloride was hydrogenated at 3 atmospheres in the presence of buffered palladium-on-charcoal catalyst. 1-Piperidino-2-methyl-3-(p-tolyl)-3-propanone was purified by distilling the base (boiling point 106-107°C/1 mm) and reconverting to the hydrochloride, melting point 216-217°C.

Therapeutic Function

Muscle relaxant, Vasodilator

Biochem/physiol Actions

Tolperisone is derived from piperidine and possesses membrane stabilizing action. It helps in reducing the effect of spasticities associated with the nervous and muscular system. It exhibits muscle relaxant action through attenuating voltage-gated sodium channels in the brain stem.

Tolperisone hydrochloride(3644-61-9)Related Product Information

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