GMDP
GMDP Basic information
- Product Name:
- GMDP
- Synonyms:
-
- d-alpha-glutamine,n-(n-acetyl-4-o-(2-(acetylamino)-2-deoxy-beta-d-glucopyrano
- glucosaminylmuramyldipeptide
- n-acetyl-beta-glucosaminyl-(1-4)-n-acetylmuramyl-l-alanyl-d-isoglutamine
- n-acetyl-beta-glucosaminyl-n-acetylmuramyl-alanylisoglutamine
- n-acetylglucosaminyl-n-acetylmuramyl-l-alanyl-d-isoglutamine
- syl)muramoyl)-l-alanyl-
- 4-(2-acetamido-2-deoxy-B-D-*glucopyranosyl)-N-ace
- N-Acetyl-D-glucosaminyl-(b1,4)-N-acetylmuramyl-L-alanyl-D-io
- CAS:
- 70280-03-4
- MF:
- C27H45N5O16
- MW:
- 695.67
- Mol File:
- 70280-03-4.mol
GMDP Chemical Properties
- storage temp.
- −20°C
MSDS
- Language:English Provider:SigmaAldrich
GMDP Usage And Synthesis
Description
N-acetyl-β-D-glucosaminyl-( 1→4)-N-acetylmuramyl-L-alanyl-D-isoglutamine was launched in Russia for hospital-related infections, psoriasis, cervical precancerous lesions and ophthalmic keratitis caused by herpes. It was found to be less pyrogenic than MDP, the minimally active component of Freund's complete adjuvant. While chemical synthesis is possible, a less laborious method (3 steps) involves the enzymatic degradation of a bacterial peptidoglycan. GDMP is orally active with a low toxicity that acts as an adjuvant to highly purified protein antigens to stimulate the induction of CD8* T-cell response. It was also able to reduce the levels of TNF-α, IL-1α and hypoglycemia induced by LPS administration and to inhibit systemic response to endotoxin.
Originator
Peptech (Australia)
Uses
N-?Acetyl-?β-?D-?glucosaminyl-?N-?acetylmuramyl-?L-?alanyl-?D-?isoglutamine acts as an immunnomodulator or immunostimulant in the treatment of various auto-immune diseases.
Definition
ChEBI: Glucosaminylmuramyl dipeptide is a dipeptide.
brand name
Likopid
GMDP(70280-03-4)Related Product Information
- N-acetyl-nor-muramyl-L-alanyl-D-isoglutamine
- ISO-PROPYL 2-ACETAMIDO-2-DEOXY-BETA-D-GLUCOPYRANOSIDE
- (R)-(+)-2-METHOXYPROPIONAMIDE
- D-GLUTAMIC ACID ALPHA-AMIDE HYDROCHLORIDE
- ETHYL 2-ACETAMIDO-2-DEOXY-BETA-D-GLUCOPYRANOSIDE
- BUTYL 2-ACETAMIDO-2-DEOXY-BETA-D-GLUCOPYRANOSIDE
- N,N'-Diacetylchitobiose
- PROPYL 2-ACETAMIDO-2-DEOXY-BETA-D-GLUCOPYRANOSIDE
- 2(2-HYDROXYETHOXY)ACETAMIDE
- Muramyl Dipeptide
- H-ALA-D-GLU-NH2
- 2-ACETAMIDO-2-DEOXY-3-O-METHYL-D-GLUCOPYRANOSE
- GMDP