Menlaquinone 7 Chemical Properties

Melting point:

54 °C

Boiling point:

bp0.0002 200° (some dec)

Density 

0.961

storage temp. 

-20°C

solubility 

Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)

form 

Solid

color 

Pale Yellow to Yellow

Stability:

Light and Temperature Sensitive

InChI

InChI=1S/C46H64O2/c1-34(2)18-12-19-35(3)20-13-21-36(4)22-14-23-37(5)24-15-25-38(6)26-16-27-39(7)28-17-29-40(8)32-33-42-41(9)45(47)43-30-10-11-31-44(43)46(42)48/h10-11,18,20,22,24,26,28,30-32H,12-17,19,21,23,25,27,29,33H2,1-9H3/b35-20+,36-22+,37-24+,38-26+,39-28+,40-32+

InChIKey

RAKQPZMEYJZGPI-LJWNYQGCSA-N

SMILES

C1(=O)C2=C(C=CC=C2)C(=O)C(C)=C1C/C=C(\C)/CC/C=C(\C)/CC/C=C(\C)/CC/C=C(\C)/CC/C=C(\C)/CC/C=C(\C)/CC/C=C(/C)\C

LogP

14.451 (est)

Safety Information

HS Code 

2936299055

Hazardous Substances Data

2124-57-4(Hazardous Substances Data)

Menlaquinone 7 Usage And Synthesis

Description

Menaquinone 7 (MK-7) is a vitamin K₂ analog that has been found in a variety of fermented foods. It increases osteocalcin, osteoprotegerin, and RANKL mRNA expression in osteoblastic MC3T3E cells. MK-7 (1 μM) increases alkaline phosphatase activity and calcium content in femoral-metaphyseal tissues isolated from normal and skeletal-unloaded rats. In vivo, MK-7 (100 μg/g diet) inhibits aortic and myocardial calcification and decreases aortic alkaline phosphatase tissue concentrations in a rat model of extraosseous calcification. It also increases trabecular number, bone mineral density, and bone mineral content in a rat model of ovariectomy-induced bone loss.

Chemical Properties

Light Yellow Crystalline Solid

Uses

Vitamin (prothrombogenic)

Uses

Vitamin K2 (MK-7)-(5,6,7,8-d₄,2-methyl-d₃) can be used as a stable isotope internal standard for data interpretation in specific biological samples.

Uses

Menaquinones are isoprenoid quinones of the naphthalene series and belongs to the K2 Vitamin homologs. Menaquinones were originally discovered as the anti-hemorrhagic factor and now encompasses a vari ety of physiological processes. Menaquinone 7 belongs to the class of K2-Vitamins homologs. Menaquinone 7 has been identified as the most bioactive cofactor for the carboxylation reaction of Gla-prote ins such as osteocalcin and matrix-Gla protein, which plays a crucial role in building and maintaining overall bone health.

Definition

ChEBI: A menaquinone whose side-chain contains seven isoprene units in an all-trans-configutation.

General Description

Vitamin K2, also known as menaquinone, is a polyisoprenoid-substituted?napthoquinone. Menaquinone-7 (MK-7) is a subtype of vitamin K2. It is found in animals, soy protein, fermented products and is primarily produced by bacteria.
Vitamin K2 (MK-7)-(5,6,7,8-d₄,2-methyl-d₃) is a deuterated vitamin K2 wherein C-5, C-6, C-7, C-8, and 2-methyl protons are replaced by deuterium.

Side effects

Menlaquinone 7 is usually well tolerated and side effects are rare. Mild digestive symptoms, such as nausea, bloating or diarrhoea, may occur with overdose, but these side effects are usually temporary and will subside on their own. There have been some reports of allergic reactions to Vitamin K2 MK7, including skin rashes and breathing difficulties. As Menlaquinone 7 interferes with the action of blood thinners such as warfarin. Therefore, if you are taking blood thinners, be sure to consult your healthcare provider before taking Vitamin K2 MK7 or any other vitamin or supplement. Therefore, if you are taking blood thinners, be sure to consult your healthcare provider before taking Vitamin K2 MK7 or any other vitamin or supplement.

Menlaquinone 7(2124-57-4)Related Product Information

• Folic acid
• Vitamin A
• Cocarboxylase
• Riboflavin
• Ascorbic Acid
• Menadione
• DL-α-Tocopherol
• Vitamin D3
• Menadione sodium bisulfite
• DL-METHIONINE METHYLSULFONIUM CHLORIDE
• DL-CARNITINE
• Menatetrenone
• 1,4-Naphthoquinone
• B12 VITAMIN B12
• Vitamin E
• Vitamin K2(35),MK7 0.13% Oil,Vitamin K2(35),MK7 1.3% Oil,Vitamin K2(35),MK7 0.13% Powder,Vitamin K2(35),MK7 1.3% Powder,Vitamin K2(35),MK-7
• Thiamine chloride
• Vitamin E calcium succinate
• Menaquinone-7