2,6-Dichloronicotinamide Chemical Properties

Melting point:

148-151 °C

Boiling point:

315.5±42.0 °C(Predicted)

Density 

1.524±0.06 g/cm3(Predicted)

storage temp. 

under inert gas (nitrogen or Argon) at 2–8 °C

form 

powder

pka

13.91±0.50(Predicted)

Appearance

White to off-white Solid

Safety Information

Hazard Codes 

Xn

Risk Statements 

22-36/37/38

Safety Statements 

26

WGK Germany 

3

HS Code 

2933399990

2,6-Dichloronicotinamide Usage And Synthesis

Uses

2,6-Dichloronicotinamide is used as a research compound and in organic synthesis, etc.

Synthesis

General procedure for the synthesis of 2,6-dichloronicotinamide from 2,6-dichloronicotinonitrile: To 2,6-dichloronicotinonitrile (1.73 g, 10 mmol) was added concentrated sulfuric acid (10 mL) and water (2 mL). The reaction mixture was heated to 90 °C and stirred continuously for 1 hour. Upon completion of the reaction, the mixture was cooled to room temperature and subsequently slowly poured into ice water. The pH of the mixture was adjusted with ammonia to 8. The precipitate precipitated was collected by filtration, washed with cold water (20 mL) and finally dried under vacuum to give 2,6-dichloronicotinamide as a brown solid (1.4 g, 73% yield). Mass spectrum (ESI): m/z = 191.1 [M + H]+.

References

[1] Patent: WO2015/48662, 2015, A2. Location in patent: Page/Page column 37
[2] Patent: CN107226805, 2017, A. Location in patent: Paragraph 0097; 0098; 0099; 0100; 0101

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