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Ciprofloxacin lactate

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Ciprofloxacin lactate Basic information

Product Name:
Ciprofloxacin lactate
Synonyms:
  • 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid lactate
  • CIPROFLOXACIN LACTATE
  • mono(2-hydroxypropanoate)
  • Ciprofloxacin lactate CP2000
  • Ciprofloxacine lactate
  • CIPROFLOXACIN-QACID
  • CIPROFLOXACIN LACTAT
  • 1-cyclopropyl-6-fluoro-4-oxo-7-piperazin-1-ylquinoline-3-carboxylic acid,2-hydroxypropanoic acid
CAS:
97867-33-9
MF:
C20H24FN3O6
MW:
421.43
EINECS:
1806241-263-5
Product Categories:
  • Antibiotic
  • API
  • Pharmacutical raw materials
  • Pharmaceutical intermediates
  • Active Pharmaceutical Ingredients
Mol File:
97867-33-9.mol
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Ciprofloxacin lactate Chemical Properties

Melting point:
255-257°C
storage temp. 
Inert atmosphere,Room Temperature
solubility 
DMSO (Slightly), Methanol (Slightly, Heated)
form 
Solid
color 
White to Off-White
CAS DataBase Reference
97867-33-9(CAS DataBase Reference)
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Safety Information

Safety Statements 
24/25
HS Code 
29339900
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Ciprofloxacin lactate Usage And Synthesis

Uses

Ciprofloxacin Lactate is an antibiotic that has been used to medicate polymer wound dressing. Ciprofloxacin Lactate has been shown to produce high and sustained serum bactericidal titers against highly susceptible bacteria.

in vivo

Ciprofloxacin (Bay-09867) lactate (30 mg/kg; i.p.; for 24 hours; BALB/c mice) has protection against Y. pestis in murine model of pneumonic plague[3].
Ciprofloxacin (Bay-09867) lactate (100 mg/kg; i.g.; daily, for 4 weeks; C57BL/6J mice) accelerates aortic root enlargement and increases the incidence of aortic dissection and rupture by decreases LOX level and increases MMP levels and activity in the aortic wall[4].
Ciprofloxacin (Bay-09867) lactate (100 mg/kg; i.g.; daily, for 4 weeks; C57BL/6J mice) induces DNA damage and release of DNA to the cytosol, mitochondrial dysfunction, and activation of cytosolic DNA sensor signaling. Ciprofloxacin lactate increases apoptosis and necroptosis in the aortic wall[4].

Animal Model:BALB/c mice[3]
Dosage:30 mg/kg
Administration:Intraperitoneal injection; for 24 hours
Result:Reduced the lung bacterial load in murine model of pneumonic plague.
Animal Model:C57BL/6J mice[4]
Dosage:100 mg/kg
Administration:Oral gavage; daily, for 4 weeks
Result:Had aortic destruction that was accompanied by decreased LOX expression and increased MMP expression and activity.
Animal Model:C57BL/6J mice[4]
Dosage:100 mg/kg
Administration:Oral gavage; daily, for 4 weeks
Result:Caused mitochondrial DNA and nuclear DNA damage, leading to mitochondrial dysfunction and ROS production. Increased apoptosis and necroptosis in the aortic wall.

IC 50

Quinolone

Ciprofloxacin lactate Preparation Products And Raw materials

Raw materials

Ciprofloxacin lactate Supplier

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