5-fluoropyrimidin-4-amine Chemical Properties

storage temp. 

under inert gas (nitrogen or Argon) at 2–8 °C

form 

claggy crystalline powder

color 

White

Safety Information

Safety Statements 

24/25

HS Code 

29335990

5-fluoropyrimidin-4-amine Usage And Synthesis

Synthesis

General procedure: pre-step A Synthesis of 5-fluoro-4-pyrimidinamine A mixture of 4-chloro-5-fluoropyrimidine (200 mg, 1.509 mmol) and ammonia (3.3 mL, 45.3 mmol) in methanol (580 μL) was placed in a microwave reactor, heated to 110 °C, and reacted for 30 min. Upon completion of the reaction, the reaction mixture was filtered and the solid product was collected and dried to give 5-fluoropyrimidin-4-amine (100 mg, 0.875 mmol, 58% yield) as a white solid. Mass spectrum (electrospray positive ion mode) m/z 114.1 ([M+H]+).

References

[1] Patent: US2013/345120, 2013, A1. Location in patent: Page/Page column
[2] Patent: US8901119, 2014, B2. Location in patent: Page/Page column

5-fluoropyrimidin-4-amine(811450-26-7)Related Product Information

• 5-Fluorouracil
• 5-Fluoropyrimidine
• 2-Methoxy-5-fluoro-4-aminopyrimidine
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• CHEMBRDG-BB 4021967
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• CHEMBRDG-BB 5376327
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• 4-AMINO-5-FLUORO-2-PIPERIDINOPYRIMIDINE
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• CHEMBRDG-BB 4015094
• 5-FLUORO-4-MORPHOLIN-4-YL-N-PYRIDIN-2-YLPYRIMIDIN-2-AMINE
• N-(2-CHLORO-5-FLUORO-4-PYRIMIDINYL)-N-(2,3-DIMETHYLPHENYL)AMINE
• 5-FLUORO-N,N'-BIS(4-METHOXYPHENYL)PYRIMIDINE-2,4-DIAMINE
• N-ALLYL-N-(2-CHLORO-5-FLUORO-4-PYRIMIDINYL)AMINE
• N,N'-BIS(2,4-DIMETHYLPHENYL)-5-FLUOROPYRIMIDINE-2,4-DIAMINE