2-(Dimethylaminomethyl)-1-cyclohexanone hydrochloride Chemical Properties

Melting point:

147-151 °C

storage temp. 

2-8°C

solubility 

Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)

form 

Crystalline Powder

color 

White

Water Solubility 

soluble

InChI

InChI=1S/C9H17NO.ClH/c1-10(2)7-8-5-3-4-6-9(8)11;/h8H,3-7H2,1-2H3;1H

InChIKey

CLVHTSWMNNSUSH-UHFFFAOYSA-N

SMILES

C1(CN(C)C)CCCCC1=O.Cl

CAS DataBase Reference

42036-65-7(CAS DataBase Reference)

Safety Information

Safety Statements 

24/25

HS Code 

29223900

MSDS

• Language:English Provider:ACROS

2-(Dimethylaminomethyl)-1-cyclohexanone hydrochloride Usage And Synthesis

Chemical Properties

white crystalline powder

Uses

An impurity found in Tramadol (T712500).

Synthesis

0.982 g (1.03 mL, 10.0 mmol) cyclohexanone, 0.360 g (12.0 mmol) paraformaldehyde, 0.816 g (10.0 mmol) dimethylammonium chloride and 4 mL ethanol are filled in a 25 mL round bottom flask with reflux condenser and magnetic stir bar. 2 drops of conc. hydrochloric acid is added, and the mixture is heated under stirring for 4 hours under reflux. The hot solution is filtered in a round bottom flask, and the solvent is evaporated by the rotary evaporator. The residue is dissolved in 2 mL ethanol under heating. At room temperature, 20 mL acetone is added to the solution. For complete crystallization, the solution is stored overnight in the freezer compartment. The crystallized crude product 2-(Dimethylaminomethyl)-1-cyclohexanone hydrochloride is sucked off over a Buechner funnel and dried in the desiccator over silica gel.

2-(Dimethylaminomethyl)-1-cyclohexanone hydrochloride(42036-65-7)Related Product Information

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• RARECHEM AQ NN 0359
• TOSLAB 869097
• SPIRO[5,5-DIMETHYL-1,3-CYCLOHEXANEDIONE-2,5'-(9'-CHLORO-3'-PHENYL-2',3',4',4A',5',6'-HEXAHYDRO-1'H-PYRAZINO[1',2'-A']QUINOLINE)]
• SPIRO[5,5-DIMETHYL-1,3-CYCLOHEXANEDIONE-2,5'-(3'-(3'-CHLOROPHENYL)-2',3',4',4A',5',6'-HEXAHYDRO-1'H-PYRAZINO[1',2'-A]QUINOLINE)]