(4-MORPHOLIN-4-YL-PHENYL)METHANOL Chemical Properties

Melting point:

96 °C

Boiling point:

378.4±42.0 °C(Predicted)

Density 

1.160±0.06 g/cm3(Predicted)

storage temp. 

Storage temp. 2-8°C

form 

powder

pka

14.40±0.10(Predicted)

color 

White

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36/37/39

Hazard Note 

Irritant

HS Code 

2934999090

(4-MORPHOLIN-4-YL-PHENYL)METHANOL Usage And Synthesis

Synthesis

C. Synthesis of 4-(4-morpholinyl)benzyl alcohol. At -10 °C, 4-(4-morpholinyl)benzoic acid (1.00 g, 4.83 mmol) and 4-methylmorpholine (0.53 mL, 4.8 mmol) were dissolved in tetrahydrofuran (25 mL), followed by the addition of ethyl chloroformate (0.46 mL, 4.8 mmol). After 0.25 h of reaction, sodium borohydride (550 mg, 14.5 mmol) was added to the mixture followed by slow addition of methanol (50 mL). Next, the mixture was treated with 5% aqueous acetic acid, after which the mixture was concentrated. The residue was purified by silica gel column chromatography (eluent: ethyl acetate/hexane) to give 164 mg (18% yield) of 4-morpholinobenzyl alcohol. The product was characterized by 1H NMR, IR spectroscopy, field desorption mass spectrometry (FD-MS, m/e 193 (M+)), and elemental analysis (calculated values for C11H15NO2: C, 68.37; H, 7.82; N, 7.25; measured values: C, 68.46; H, 7.95; N, 7.21).

References

[1] Patent: US6610704, 2003, B1

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