1,2-PHENYLENE PHOSPHOROCHLORIDITE Chemical Properties

Melting point:

30-35 °C(lit.)

Boiling point:

80 °C20 mm Hg(lit.)

Density 

1.466 g/mL at 25 °C(lit.)

refractive index 

n20/D 1.571(lit.)

Flash point:

>230 °F

storage temp. 

0-6°C

solubility 

Benzene (Slightly), Chloroform (Slightly)

form 

solid

Sensitive 

Moisture Sensitive

BRN 

135455

Stability:

Moisture Sensitive

CAS DataBase Reference

1641-40-3(CAS DataBase Reference)

EPA Substance Registry System

1,3,2-Benzodioxaphosphole, 2-chloro- (1641-40-3)

Safety Information

Hazard Codes 

C

Risk Statements 

34

Safety Statements 

26-36/37/39-45

RIDADR 

UN 3261 8/PG 2

WGK Germany 

3

F 

10-21

TSCA 

Yes

HazardClass 

8

PackingGroup 

II

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

1,2-PHENYLENE PHOSPHOROCHLORIDITE Usage And Synthesis

Chemical Properties

Colourless Liquid Which Solidifies at Low Temperature

Uses

Highly reactive cyclic phosphitylating reagent which provides fast coupling rates, and hydrolytic cleavage occurs more readily than with acyclic analogs

Uses

• Catalyst in synthesis of bakkane sesquiterpenes
• Reactant in reversible halogen-halogen ligand substitution at room temperature, and in irreversible halogen-O substitution at higher temperatures
• Reactant in preparation of gold(I) trimethoxybenzonitrile phosphine isolated precatalysts
• Reactant for preparation of pyrroles by TMSOTf-catalyzed Arbuzov reaction
• Phosphorylation agent
• Reactant for reparation of vinyl-substituted spirophosphoranes and vinylphosphonates via Markovnikov addition

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