2-Chloro-3-nitropyridine-6-amine Chemical Properties

Melting point:

188 °C

Boiling point:

393.6±37.0 °C(Predicted)

Density 

1.596±0.06 g/cm3(Predicted)

storage temp. 

Keep in dark place,Inert atmosphere,Room temperature

pka

-1.22±0.37(Predicted)

Appearance

Yellow to green Solid

2-Chloro-3-nitropyridine-6-amine Usage And Synthesis

Synthesis

The general procedure for the synthesis of 2-amino-5-nitro-6-chloropyridine from 2-amino-6-chloropyridine was as follows: concentrated nitric acid (2.39 mL, 35.00 mmol) was slowly added dropwise at 0 °C to a mixture containing concentrated sulfuric acid (56 mL, 1050 mmol) and 6-chloropyridin-2-amine (3.00 g, 23.34 mmol). The reaction mixture was kept stirred at 0 °C for 4 hours. After completion of the reaction, the mixture was carefully poured into ice water. The mixture was extracted with ethyl acetate (3 x 100 mL). The organic layers were combined, dried with anhydrous sodium sulfate and subsequently concentrated. The residue was purified by column chromatography to afford the target product 2-amino-5-nitro-6-chloropyridine (1.38 g, 34% yield).

References

[1] Patent: WO2018/146472, 2018, A1. Location in patent: Page/Page column 54; 55
[2] Patent: WO2018/146469, 2018, A1. Location in patent: Page/Page column 44-45

2-Chloro-3-nitropyridine-6-amine(84487-03-6)Related Product Information

• 2-Chloro-3-nitropyridine
• 2-chloro-3-nitro-6-hydroxypyridine
• 6-Chloro-5-nitropyridine-2-carboxylic acid