2-CHLORO-5-FLUOROBENZYL ALCOHOL Chemical Properties

Melting point:

68-72°C

Boiling point:

229.6±25.0 °C(Predicted)

Density 

1.344±0.06 g/cm3(Predicted)

storage temp. 

Sealed in dry,Room Temperature

pka

13.65±0.10(Predicted)

Appearance

White to off-white Solid

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36/37/39

HazardClass 

IRRITANT

HS Code 

2906290090

MSDS

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2-CHLORO-5-FLUOROBENZYL ALCOHOL Usage And Synthesis

Synthesis

The synthesis of 2-chloro-5-fluorobenzyl alcohol proceeded as follows:

Step 1: Compound Z-A-1-a (35g, 0.2 mol) was dissolved in methanol (500mL) and concentrated sulfuric acid (5mL) was added slowly. The reaction solution was stirred under the protection of N 2 at 70??C for 18 h. Most of the solvent was spun off, then 200 mL of water was added and extracted with ethyl acetate (3x250 mL), dried and spun dry to obtain the red oily material Z-A-1-b (38 g, 100% yield).

Step 2: Compound Z-A-1-b (38g, 0.2 mol) was dissolved in THF (200mL) and methanol (50mL), sodium borohydride (15.4g, 0.4 mol) was added slowly at 0??C, and the reaction was stirred at room temperature for 2h. The disappearance of the reaction material was monitored by TLC, and the reaction solution was cooled down to 0??C with the addition of 300mL of water, and was extracted with dichloromethane (3x300mL), the organic phase was washed with saturated sodium bicarbonate (500mL), the organic phase was dried and spun dry to obtain a yellow solid 2-chloro-5-fluorobenzyl alcohol (32g, yield 99%).

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