3'-Chloropropiophenone Chemical Properties

Melting point:

45-47 °C(lit.)

Boiling point:

124 °C14 mm Hg(lit.)

Density 

1.1115 (rough estimate)

refractive index 

1.5350 (estimate)

Flash point:

>230 °F

storage temp. 

Sealed in dry,Room Temperature

solubility 

Soluble in methanol.

form 

Crystalline Solid

color 

White to light yellow

InChI

InChI=1S/C9H9ClO/c1-2-9(11)7-4-3-5-8(10)6-7/h3-6H,2H2,1H3

InChIKey

PQWGFUFROKIJBO-UHFFFAOYSA-N

SMILES

C(C1=CC=CC(Cl)=C1)(=O)CC

LogP

3.041

CAS DataBase Reference

34841-35-5(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

37/39-26-24/25

WGK Germany 

3

HS Code 

29147000

MSDS

• Language:English Provider:1-(3-Chlorophenyl)-1-propanone
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

3'-Chloropropiophenone Usage And Synthesis

Description

Influence of solvents and temperature on the yield and enantioselectivity of the phenylation of 3′-chloropropiophenone has been investigated.

Chemical Properties

WHITE TO LIGHT YELLOW CRYSTALLINE SOLID

Uses

3'-Chloropropiophenone has been used in the preparation of 1-(3-chlorophenyl)-1-phenyl-1-propanol.

Uses

3'-Chloropropiophenone is a reagent used in the vinylation, alkylation and dienylation of ketones. It is also used in the preparation of thizaine derivatives that show antibacterial activity.

Application

3′-Chloropropiophenone can be used as a reactant to synthesize:
(S)-3-chloro-1-phenylpropanol via bio-catalyzed asymmetric reduction method.
1-(3-Chlorophenyl)-1-phenyl-1-propanol by phenylation with diphenylzinc in the presence of dihydroxy bis(sulfonamide) ligand.
(S)-Dapoxetine, a selective serotonin reuptake inhibitor.

Preparation

4.86 g (0.2 mol) of magnesium turnings, 30 ml of dry diethyl ether and a grain of iodine are placed in a one liter three-necked round-bottomed flask equipped with a condenser, a calcium chloride drying tube, a pressure equalizing funnel and a magnetic stirrer; the flask is purged with nitrogen, and 21.8 g (0.2 mol) of ethyl bromide in 30 ml of dry diethyl ether are then added. The mixture is then heated under reflux for one hour and left to cool. At ambient temperature, 16.51 g (0.12 mol) of 3-chlorobenzonitrile in 70 ml of dry diethyl ether are then added. A copious precipitate forms. The mixture is stirred overnight at ambient temperture and then cooled in an ice bath and hydrolysed by slowly adding 50 ml of water and then about 100 ml of 6N hydrochloric acid until the pH is acid. The mixture is stirred for one and a half hours and then extracted with ethyl acetate. The organic extract is then washed twice with water, dried and concentrated on a rotary evaporator. This gives 26 g of an orange oil, which is concentrated in vacuo to give about 18.2 g of ochre crystals of 3'-chloropropiophenone melting at about 40° C.
Literature source US04690931

Synthesis

In a high-pressure reactor equipped with a 10 mL PTFE liner, NiBr2-diglycol dimethyl ether (5 mol%), 1,10-phenanthroline (10 mol%) and a magnetic stirrer were added sequentially. Subsequently, 3-chlorophenylboronic acid (1.0 mmol), NaHCO3 (2.0 equiv), H2O (2.0 mmol) and propionitrile (1.0 mL) were added to the reactor. After sealing the autoclave, it was cooled to low temperature in liquid nitrogen, followed by evacuation and addition of HCFC-244bb (2.0 mL, 2.6 g) by self-priming. The autoclave was transferred to a 100 °C oil bath and the reaction was stirred for 5 hours. Upon completion of the reaction, the autoclave was cooled to room temperature and the excess HCFC-244bb was slowly released. water (30 mL) was added to the reaction mixture and extracted with dichloromethane (3 x 15 mL). The organic phases were combined, washed with saturated saline, dried over anhydrous Na2SO4 and concentrated under reduced pressure to remove the organic solvent. The crude product was purified by column chromatography.

References

[1] Synlett, 2018, vol. 29, # 5, p. 593 - 596

3'-Chloropropiophenone(34841-35-5)Related Product Information

• 3-Chlorophenol
• Acetylacetone
• Calcium pyruvate
• Hexachloroacetone
• 1,3-Dichlorobenzene
• 4'-Chloropropiophenone
• 1,1,3-Trichloroacetone
• 1-Chloro-3-nitrobenzene
• Chlorphenamine maleate
• Citric acid monohydrate
• 3'-Hydroxypropiophenone
• Pyruvic acid
• 3-Chloroanisole
• 3-Chloropropiophenone
• 3-Chlorobenzonitrile
• BUPROPION MORPHOLINOL
• 1-(3-Chlorophenyl)-1,2-propanedione
• Bupropion Hydrochloride Related Compound A (15 mg) (2-(tert-butylamino)-4'-chloropropiophenone hydrochloride)