(4-AMINOMETHYL-PHENYL)-METHANOL Chemical Properties

Melting point:

80-82°C

Boiling point:

280.0±20.0 °C(Predicted)

Density 

1.113±0.06 g/cm3(Predicted)

storage temp. 

Keep in dark place,Inert atmosphere,2-8°C

solubility 

DMSO, Methanol

form 

Solid

pka

14.44±0.10(Predicted)

color 

Off-White

InChI

InChI=1S/C8H11NO/c9-5-7-1-3-8(6-10)4-2-7/h1-4,10H,5-6,9H2

InChIKey

WMOUKOAUAFESMR-UHFFFAOYSA-N

SMILES

C1(CO)=CC=C(CN)C=C1

Safety Information

Hazard Codes 

Xi

Risk Statements 

41

Safety Statements 

26-39

HS Code 

2922190090

(4-AMINOMETHYL-PHENYL)-METHANOL Usage And Synthesis

Chemical Properties

Off-White Solid

Synthesis

A reduction reaction was carried out using 4-hydroxymethylbenzonitrile (2.0 g, 15 mmol) as a raw material in MeOH:NH3 (100 ml) solution under hydrogen (50 psi) atmosphere for 20 hrs using nickel Nguyenay (0.5 g) as a catalyst. Upon completion of the reaction, the reaction mixture was filtered through a diatomaceous earth pad to remove the catalyst. The filtrate was concentrated under reduced pressure to afford a white solid (4-aminomethylphenyl) methanol hydrochloride (2.01 g, 98% yield), which was pure enough to be used directly in the subsequent reaction without further purification. The product characterization data were as follows: mass spectrum (APCI+): m/z 138.3 (M+H)+; 1H-NMR (DMSO-d6) δ 7.20 (s, 4H), 5.04 (s, 2H), 4.42 (s, 2H), 3.83 (s, 1H), 2.45 (s, 2H).

References

[1] Patent: WO2005/56004, 2005, A1. Location in patent: Page/Page column 154-155
[2] ACS Catalysis, 2018, vol. 8, # 10, p. 9125 - 9130
[3] Journal of Organic Chemistry, 1998, vol. 63, # 22, p. 7663 - 7669
[4] Patent: US2015/259291, 2015, A1. Location in patent: Paragraph 0612
[5] Patent: WO2007/124136, 2007, A1. Location in patent: Page/Page column 130

(4-AMINOMETHYL-PHENYL)-METHANOL(39895-56-2)Related Product Information

• Methyl 4-(aminomethyl)benzoate
• 4-(Aminomethyl)benzoic acid
• 2-(4-FLUORO-PHENYL)-1,3-DIOXO-2,3-DIHYDRO-1H-ISOINDOLE-5-CARBOXYLIC ACID
• 4-AMIDINOBENZOIC ACID
• FLUORESCEIN-5(6)-CARBOXAMIDOCAPROIC ACID N-SUCCINIMIDYL ESTER
• 4-(1,3-DIOXOLAN-2-YL)BENZENE-1-CARBOTHIOAMIDE
• 2-(3-FLUORO-PHENYL)-1,3-DIOXO-2,3-DIHYDRO-1H-ISOINDOLE-5-CARBOXYLIC ACID
• 4-(BOC-AMINOMETHYL-PHENYL)-METHANOL
• [2-(aminomethyl)phenyl]methanol
• (3-(aminomethyl)phenyl)methanol
• 2-(4-NITROPHENYL)-1,3-DIOXOISOINDOLINE-5-CARBOXYLIC ACID
• 2-(4-HYDROXYPHENYL)-1,3-DIOXO-2,3-DIHYDRO-1H-ISOINDOLE-5-CARBOXYLIC ACID
• METHYL 4-([3-NITRO-2-OXO-5-(TRIFLUOROMETHYL)-1(2H)-PYRIDINYL]METHYL)BENZENECARBOXYLATE
• METHYL 4-([2-OXO-5-(TRIFLUOROMETHYL)-1(2H)-PYRIDINYL]METHYL)BENZENECARBOXYLATE
• 2-(3-(1-(4-CARBOXY) BENZYL-3-METHYL-6-TRIFLUORO METHYL-2-BENZIMIDAZOLINYLIDENE) PROPENYL)-3-METHYL-1-(4-CARBOXY) BENZYL-6-TRIFLUOROMETHYL BENZIMIDAZOLIUM HYDROXIDE, INNER SALT
• methyl 2-(2-methoxy-2-oxoethyl)-1,3-dioxoisoindoline-5-carboxylate
• ethyl 4-amidinobenzoate
• 4-([2-OXO-5-(TRIFLUOROMETHYL)-1(2H)-PYRIDINYL]METHYL)BENZENECARBOXYLIC ACID