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DMT-dG(ib) Phosphoramidite

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DMT-dG(ib) Phosphoramidite Basic information

Product Name:
DMT-dG(ib) Phosphoramidite
Synonyms:
  • dG(N-ibu) Phosphoramidite
  • N-blocked-5'-O-DMT 3'-CED deoxyguanosine phosphoramidite
  • 5'-O-(4,4-Dimethoxytrityl)-N-isobutyryl-2'-deoxyguanosine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite
  • 5'-O-(4,4'-DIMETHOXYTRITYL)-N2-ISOBUTYRYL-2'-DEOXYGUANOSINE-3'-(2-CYANOETHYL-N,N-DIISOPROPYL)PHOSPHORAMIDITE
  • N2-(ISOBUTYRYL)-5'-O-(DIMETHOXYTRITYL)-2'-DEOXYGUANOSINE-3'-N,N-DIISOPROPYL (CYANOETHYL) PHOSPHORAMIDITE
  • deoxyguanosine-ce phosphoramidite*for cyclone
  • DNA G Phosphoramidite
  • DMT-dG(dmf) Amidite 5g, Single
CAS:
93183-15-4
MF:
C44H54N7O8P
MW:
839.92
EINECS:
685-519-6
Product Categories:
  • Pharmaceutical
  • RNAi
  • Amidite
Mol File:
93183-15-4.mol
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DMT-dG(ib) Phosphoramidite Chemical Properties

Density 
1.22 at 20℃
vapor pressure 
0-0Pa at 20-50℃
storage temp. 
Sealed in dry,2-8°C
solubility 
soluble, clear
form 
powder or granules
pka
9.16±0.20(Predicted)
color 
white to off-white
InChI
InChI=1/C44H54N7O8P/c1-28(2)41(52)48-43-47-40-39(42(53)49-43)46-27-50(40)38-25-36(59-60(57-24-12-23-45)51(29(3)4)30(5)6)37(58-38)26-56-44(31-13-10-9-11-14-31,32-15-19-34(54-7)20-16-32)33-17-21-35(55-8)22-18-33/h9-11,13-22,27-30,36-38H,12,24-26H2,1-8H3,(H2,47,48,49,52,53)/t36-,37+,38+,60?/s3
InChIKey
FDRMKYVTIFSDPR-MMROLVBFSA-N
SMILES
C(OC[C@H]1O[C@@H](N2C=NC3C(=O)NC(NC(=O)C(C)C)=NC2=3)C[C@@H]1OP(OCCC#N)N(C(C)C)C(C)C)(C1=CC=CC=C1)(C1=CC=C(OC)C=C1)C1=CC=C(OC)C=C1 |&1:3,5,23,r|
LogP
4.17 at 20℃
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Safety Information

Safety Statements 
24/25
WGK Germany 
3
HS Code 
29349990
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DMT-dG(ib) Phosphoramidite Usage And Synthesis

Uses

2’-Deoxy-5’-O-DMT-N2-isobutyrylguanosine 3’-CE Phosphoramidite is used to prepare antisense oligonucleotides containing conformationally constrained methoxyaminomethylene and aminooxymethylene and aminomethylene bridged nucleoside analogs.

Definition

5'-O-DMT-N2-Isobutyryl-2'-Deoxyguanosine-CE Phosphoramidite (DMT-dG(ib) Phosphoramidite) is a nucleoside phosphoramidite that contains an isobutyryl group, and it can be used in the synthesis of oligonucleotides.

storage

-20°C, stored under nitrogen.
In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

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