Rhodanine Chemical Properties

Melting point:

165-169 °C(lit.)

Density 

0.868

refractive index 

1.5231 (estimate)

storage temp. 

-20°C

solubility 

methanol: soluble0.5g/10 mL, clear, colorless to greenish-yellow

form 

Fine Crystalline Powder

pka

pK (25°) 5.52

color 

Light yellow to beige

Water Solubility 

SOLUBLE IN HOT WATER

Merck 

14,8184

BRN 

110701

CAS DataBase Reference

141-84-4(CAS DataBase Reference)

NIST Chemistry Reference

2-Thioxo-4-thiazolidinone(141-84-4)

EPA Substance Registry System

Rhodanine (141-84-4)

Safety Information

Hazard Codes 

Xn

Risk Statements 

22-41

Safety Statements 

22-26-39

RIDADR 

3288

WGK Germany 

3

RTECS 

VI7700000

TSCA 

Yes

HazardClass 

6.1(a)

PackingGroup 

II

HS Code 

29341000

Hazardous Substances Data

141-84-4(Hazardous Substances Data)

MSDS

• Language:English Provider:2-Thio-2,4-thiazolidinedione
• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

Rhodanine Usage And Synthesis

Chemical Properties

light yellow to beige fine crystalline powder

Uses

thiadiazole pharmaceutical intermediate

Uses

In the case of reagents containing several potential donor atoms, one of the first steps in the study of complex formation is the specification of the functional groups which actually participate in the complexation reaction. The literature on rhodanine derivatives provides a good example of such examinations.

Uses

In the synthesis of phenylalanine.

Definition

ChEBI: Rhodanine is a thiazolidinone.

General Description

Light yellow crystals. Density 0.868 g / cm3. Melting point 168.5°C. May explode on rapid heating.

Air & Water Reactions

Water soluble.

Reactivity Profile

Rhodanine may generate hydrogen sulfide with acids. May generate heat and hydrogen gas with alkali metals, nitrides, hydrides, and other strong reducing agents.

Hazard

May explode when heated to 166C. Toxic by ingestion.

Biochem/physiol Actions

Rhodanine inhibits the multiplication of echovirus 12 and the development of virus-induced morphologic changes.

Purification Methods

Crystallise rhodanine from glacial acetic acid or water. It is used to estimate Ag and gallic acid [Thies & Fischer Microchimica Acta 809 1973]. [Beilstein 27 H 242, 27 I 309, 27 II 288, 27 III/IV 3188.]

Rhodanine(141-84-4)Related Product Information

• Rhodanine-3-acetic acid
• Methylchloroisothiazolinone/methylisothiazolinone mixture (MCIT/MIT)
• Thioacetic acid
• Thiourea
• 2-Thiobarbituric acid
• FLAVANONE
• 1.10-Phenanthroline
• Tannic acid
• 2,4-Thiazolidinedione
• Ammonium thiosulfate
• Thioacetamide
• Polyvinylpyrrolidone
• 2-Methyl-4-isothiazolin-3-one
• 1,2-Benzisothiazol-3(2H)-one
• Sodium thiosulfate
• Rhodium(II) acetate dimer
• Rhodiumtriphenylacetate
• Rhodium(III) Chloride