N-OMEGA-METHYLSEROTONIN OXALATE SALT Chemical Properties

Melting point:

161-162 °C (dec.)(lit.)

storage temp. 

2-8°C

solubility 

DMF: 3 mg/mL; DMSO: 3 mg/mL; PBS (pH 7.2): 2.5 mg/mL

form 

A crystalline solid

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-37/39

WGK Germany 

3

MSDS

• Language:English Provider:SigmaAldrich

N-OMEGA-METHYLSEROTONIN OXALATE SALT Usage And Synthesis

Description

5-hydroxy-N^ω-methyl Tryptamine is a metabolite of serotonin (5-HT; ) in humans that has also been found in plants. It is an agonist of the 5-HT receptor subtype 5-HT₇ (IC₅₀ = 23 pM in a radioligand binding assay). 5-hydroxy-N^ω-methyl Tryptamine increases intracellular cyclic AMP production in HEK293 cells expressing 5-HT₇ (EC₅₀ = 22 nM). It inhibits serotonin uptake in HEK293 cells expressing human serotonin transporters (IC₅₀ = 490 nM). Elevated levels of urinary 5-hydroxy-N^ω-methyl tryptamine have been found in patients with schizophrenia, depression, and epilepsy.

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