Basic information Safety Supplier Related

N-(3-PYRIDYL)-INDOMETHACIN AMIDE

Basic information Safety Supplier Related

N-(3-PYRIDYL)-INDOMETHACIN AMIDE Basic information

Product Name:
N-(3-PYRIDYL)-INDOMETHACIN AMIDE
Synonyms:
  • N-(3-PYRIDYL)-1-(4-CHLOROBENZOYL)-5-METHOXY-2-METHYL-1H-INDOLE-3-ACETAMIDE
  • N-(3-PYRIDYL)-1-P-CHLOROBENZOYL-5-METHOXY-2-METHYLINDOLE-3-ACETAMIDE
  • N-(3-PYRIDYL)-INDOMETHACIN AMIDE
  • N-3PYIA
  • N-3PyIA, N-(3-Pyridyl)-1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetamide
  • 1-(4-Chlorobenzoyl)-5-Methoxy-2-Methyl-N-3-pyridinyl-1H-indole-3-acetaMide
  • 2-[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]-N-pyridin-3-ylacetamide
  • Indomethacin N-Pyridyl Impurity
CAS:
261766-29-4
MF:
C24H20ClN3O3
MW:
433.89
Product Categories:
  • Inhibitors
Mol File:
Mol File
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N-(3-PYRIDYL)-INDOMETHACIN AMIDE Chemical Properties

storage temp. 
−20°C
solubility 
≤3mg/ml in ethanol;3mg/ml in DMSO;3mg/ml in dimethyl formamide
form 
crystalline solid
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Safety Information

WGK Germany 
3

MSDS

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N-(3-PYRIDYL)-INDOMETHACIN AMIDE Usage And Synthesis

Uses

An aromatic amide of indomethacin recently reported to be a potent and selective reversible inhibitor of COX-2. Inhibits human recombinant COX-2 with IC50 of 0.1 uM.

Biological Activity

n-(3-pyridyl)-indomethacin amide is a reversible, potent and selective cox-2 inhibitor [1].cyclooxygenase (cox) is an enzyme responsible for formation of prostanoids, including thromboxane and prostaglandins such as prostacyclin. cox-1 is the constitutive isoform and is mainly responsible for the synthesis of cytoprotective prostaglandins in the gastrointestinal tract (gi) and of the proaggregatory thromboxane in blood platelets. cox-2 is inducible and short-lived that is stimulated by endotoxin, cytokines, and mitogens. cox-2 plays important roles in prostaglandin biosynthesis in inflammatory cells the central nervous system [1].n-(3-pyridyl)-indomethacin amide (n-3pyia) is a reversible, potent and selective cox-2 inhibitor that inhibits human recombinant cox-2 and ovine cox-1 with ic50 values of 0.052 and >66 μm, respectively. it is over 1300 times less potent as an inhibitor of ovine cox-1. n-(3-pyridyl)-indomethacin amide is the 3-pyridyl amide derivative of indomethacin that shows selective against cox-2 [1].

References

[1]. kalgutkar as, marnett ab, crews bc, et al. ester and amide derivatives of the nonsteroidal antiinflammatory drug, indomethacin, as selective cyclooxygenase-2 inhibitors. j med chem. 2000 jul 27;43(15):2860-70.

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