2,3-BIS(BROMOMETHYL)QUINOXALINE 1,4-DIOXIDE
2,3-BIS(BROMOMETHYL)QUINOXALINE 1,4-DIOXIDE Basic information
- Product Name:
- 2,3-BIS(BROMOMETHYL)QUINOXALINE 1,4-DIOXIDE
- Synonyms:
-
- 2,3-BIS(BROMOMETHYL)QUINOXALINE 1,4-DIOXIDE
- 2,3-bis(broMoMethyl)-1-oxoquinoxalin-1-iuM-4(1H)-olate
- Conoidin A
- Quinoxaline, 2,3-bis(bromomethyl)-, 1,4-dioxide
- antioxidative,antioxidant,heart disease,Parasite,Inhibitor,Peroxiredoxin II,hyperperoxidation,Conoidin A,ischaemic,inhibit,neuroprotective
- Conoidin A, 10 mM in DMSO
- Peroxiredoxin Inhibitor, Conoidin A
- CAS:
- 18080-67-6
- MF:
- C10H8Br2N2O2
- MW:
- 347.99
- Mol File:
- 18080-67-6.mol
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2,3-BIS(BROMOMETHYL)QUINOXALINE 1,4-DIOXIDE Chemical Properties
- Melting point:
- 180-190 °C (decomp)
- Boiling point:
- 512.3±60.0 °C(Predicted)
- Density
- 1.95±0.1 g/cm3(Predicted)
- storage temp.
- -20°C
- solubility
- DMF: 25 mg/ml; DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml; DMSO: 20 mg/ml
- form
- A crystalline solid
- pka
- 1.91±0.30(Predicted)
- color
- White to yellow
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2,3-BIS(BROMOMETHYL)QUINOXALINE 1,4-DIOXIDE Usage And Synthesis
Uses
Conoidin A is a peroxiredoxin inhibitor.
Biological Activity
Cell permeable: yes', 'Primary Target
Peroxiredoxin', 'Reversible: no', 'Target IC50: 23 μM for blocking TgPrxII hyperperoxidation activity
in vivo
Conoidin A (intraperitoneal injection; 5 mg/kg; for three successive days before MI/R injury) blocks the effect of Luteolin (HY-N0162) on the ST-segment elevation. Furthermore, an increase in the infarct size presented of the MI/R group can be reduced by Luteolin. But pre-treatment with conoidin A abolishs the effect of Luteolin. Pre-treatment with conoidin A also prevents Luteolin-reduced activities of CK-MB, AST and LDH in vivo[3].
| Animal Model: | Rat myocardial I/R model[3] |
| Dosage: | 5?mg/kg |
| Administration: | Intraperitoneal injection; 5?mg/kg; for three successive days before MI/R injury |
| Result: | Significantly reversed the antioxidative effect of Luteolin. Impaired the protective effects of luteolin. |
IC 50
Toxoplasma
2,3-BIS(BROMOMETHYL)QUINOXALINE 1,4-DIOXIDESupplier
Candia Thamtech Company Limited
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Shanghai YuLue Chemical Co., Ltd.
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Nanjing Chalf-Pharm Technology Co., Ltd.
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- 025-57018978 18251899859
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Shanghai Lollane Biological Technology Co.,Ltd.
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Shanghai YuanYe Biotechnology Co., Ltd.
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- 021-61312847; 18021002903
- 3008007409@qq.com
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2,3-BIS(BROMOMETHYL)QUINOXALINE 1,4-DIOXIDE(18080-67-6)Related Product Information
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