6-BROMO-2-PYRIDINEMETHANAMINE, HYDROCHLORIDE Chemical Properties

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

Safety Information

Hazard Codes 

T

Risk Statements 

25

Safety Statements 

45

RIDADR 

UN2811

HazardClass 

6.1

HS Code 

2933399990

6-BROMO-2-PYRIDINEMETHANAMINE, HYDROCHLORIDE Usage And Synthesis

Uses

6-Bromo-2-pyridinemethylamine hydrochloride is the form of 6-bromo-2-pyridinemethylamine hydrochloride. 6-Bromo-2-pyridinemethylamine is an important organic intermediate that can be prepared from 2-bromo-6-hydroxymethylpyridine and can be used in laboratory research and development processes as well as in chemical and pharmaceutical synthesis processes.

Synthesis

2- [(6-Bromopyridin-2-yl)methyl]-2,3-dihydro-1H-isoindole-1,3-dione (2.5 g, 7.88 mmol, 1.0 eq.) was dissolved in anhydrous ethanol (78 mL) in a 250 mL round-bottomed flask fitted with a magnetic stirring bar and a condenser and heated to reflux until completely dissolved (~15 min). Hydrazine monohydrate (1.58 g, 1.53 mL, 31.53 mmol, 4.0 eq.) was added to the homogeneous solution. Within one minute, the reaction mixture turned yellow. The reaction mixture was heated for 3 hours, during which time the mixture solidified into a white thick suspension. Another 50 mL of ethanol was added and the mixture was stirred for another 2 hours. The reaction was cooled to room temperature and then to 0 C to precipitate the hydrazine/phthalimide adduct that disintegrated in solution. The precipitate was filtered over a Buchner. The precipitate was washed well with anhydrous ethanol and the filtrate was partially concentrated. Some solids remained in the suspension, which was then filtered with cold EtOH. The filtrate was concentrated to dryness to give a solid.

6-BROMO-2-PYRIDINEMETHANAMINE, HYDROCHLORIDE(914947-26-5)Related Product Information

• Pyridine
• Betahistine
• 6-BROMO-2-PYRIDINEMETHANAMINE