8-PRENYLGENISTEIN Chemical Properties

Melting point:

133-135℃

Boiling point:

583.5±50.0 °C(Predicted)

Density 

1.351±0.06 g/cm3(Predicted)

storage temp. 

4°C, protect from light

solubility 

DMSO : 100 mg/mL (295.55 mM; Need ultrasonic)

form 

Powder

pka

6.62±0.20(Predicted)

color 

Off-white to light yellow

8-PRENYLGENISTEIN Usage And Synthesis

Uses

Lupiwighteone is a natural product derivative of Genistein (G350000). Genistein exhibits specific inhibitory activity against tyrosine kinases, including autophosphorylation of epidermal growth factor receptor kinase (IC50 - 2.6uM). Also inhibits other protein kinases through competitive inhibition of ATP. Inhibits tumor cell proliferation and induces tumor cell differentiation. Produces cell-cycle arrest and apoptosis in Jurat T-leukemia cells. However, it prevents anti-CD3 monoclonal antibody-induced thymic apoptosis. Genistein also inhibits topoisomerase II activity in vitro. Genistein has also been shown to inhibit the action of GABA on recombinant GABAA receptors 2. uv(max)ethanol: 262.5 nm (e= 138). moderately sol. in hot alcohol.

Definition

ChEBI: Lupiwighteone is a member of isoflavones.

target

PARP | Bcl-2/Bax | Caspase | Akt | CDK | ROS | P450 (e.g. CYP17)

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