AZD1152 Chemical Properties

Density 

1.463

storage temp. 

under inert gas (nitrogen or Argon) at 2–8 °C

solubility 

insoluble in H2O; insoluble in EtOH; ≥5.88 mg/mL in DMSO

form 

solid

pka

1.75±0.10(Predicted)

AZD1152 Usage And Synthesis

Uses

Barasertib. is a selective inhibitor of Aurora B kinase, which inhibits human tumor xenograft growth by inducing apoptosis.

Definition

ChEBI: AZT-1152 is a dihydrogen phosphate prodrug of a pyrazoloquinazoline aurora kinase inhibitor AZD1152-hydroxyquinazoline pyrazol anilide(HQPA) and is converted rapidly to the active AZD1152-HQPA in plasma. It has a role as a prodrug, an antineoplastic agent and an Aurora kinase inhibitor. It is a member of quinazolines, a monoalkyl phosphate, an anilide, a member of monofluorobenzenes, a member of pyrazoles, a secondary amino compound, a secondary carboxamide and a tertiary amino compound. It is functionally related to an AZD-1152.

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