AZD1152
AZD1152 Basic information
- Product Name:
- AZD1152
- Synonyms:
-
- 1H-Pyrazole-3-acetamide, 5-[[7-[3-[ethyl[2-(phosphonooxy)ethyl]amino]propoxy]-4-quinazolinyl]amino]-N-(3-fluorophenyl)-
- AZD1152
- 5-[[7-[3-[Ethyl[2-(phosphonooxy)ethyl]amino]propoxy]-4-quinazolinyl]amino]-N-(3-fluorophenyl)-1H-pyrazole-3-acetamide
- BARASERTIB; AZD-1152; AZD 1152
- Barasertib (AZD1152)
- CS-1053
- 2-[[3-({4-[(5-{2-[(3-fluorophenyl)amino]-2-oxoethyl}-1H-pyrazol-3-yl)amino]quinazolin-7-yl}oxy)propyl](ethyl)amino]ethyl dihydrogen phosphate
- 2-(Ethyl(3-((4-((3-(2-((3-fluorophenyl)amino)-2-oxoethyl)-1H-pyrazol-5-yl)amino)quinazolin-7-yl)oxy)propyl)amino)ethyl dihydrogen phosphate
- CAS:
- 722543-31-9
- MF:
- C26H31FN7O6P
- MW:
- 587.54
- Mol File:
- 722543-31-9.mol
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AZD1152 Chemical Properties
- Density
- 1.463
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- solubility
- insoluble in H2O; insoluble in EtOH; ≥5.88 mg/mL in DMSO
- form
- solid
- pka
- 1.75±0.10(Predicted)
- color
- Off-white to light yellow
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AZD1152 Usage And Synthesis
Uses
Barasertib. is a selective inhibitor of Aurora B kinase, which inhibits human tumor xenograft growth by inducing apoptosis.
Definition
ChEBI: AZT-1152 is a dihydrogen phosphate prodrug of a pyrazoloquinazoline aurora kinase inhibitor AZD1152-hydroxyquinazoline pyrazol anilide(HQPA) and is converted rapidly to the active AZD1152-HQPA in plasma. It has a role as a prodrug, an antineoplastic agent and an Aurora kinase inhibitor. It is a member of quinazolines, a monoalkyl phosphate, an anilide, a member of monofluorobenzenes, a member of pyrazoles, a secondary amino compound, a secondary carboxamide and a tertiary amino compound. It is functionally related to an AZD-1152.
AZD1152Supplier
Capot Chemical Co., Ltd
- Tel
- +86 (0) 571 85 58 67 18
- sales@capotchem.com
Shanghai Topbiochem Technology Co., Ltd
- Tel
- 021-58170097
- info@topbiochem.com
NCE Biomedical Co.,Ltd.
- Tel
- 4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988
Haoyuan Chemexpress Co., Ltd.
- Tel
- 021-58950125
- info@chemexpress.com
MedChemexpress LLC
- Tel
- 021-58955995
- sales@medchemexpress.cn
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