3-Amino-4-methoxybenzanilide Chemical Properties

Melting point:

154-156°C

Boiling point:

385.1°C (rough estimate)

Density 

1.1338 (rough estimate)

vapor pressure 

0-0Pa at 25℃

refractive index 

1.6419 (estimate)

storage temp. 

Keep in dark place,Inert atmosphere,Room temperature

solubility 

DMSO (Slightly), Methanol (Slightly)

form 

Solid

pka

13.44±0.70(Predicted)

color 

White to Off-White

LogP

2.08 at 23℃ and pH7

CAS DataBase Reference

120-35-4(CAS DataBase Reference)

EPA Substance Registry System

Benzamide, 3-amino-4-methoxy-N-phenyl- (120-35-4)

Safety Information

Risk Statements 

36/37/38

Safety Statements 

26-36/37/39

RTECS 

CV7400000

TSCA 

Yes

HazardClass 

IRRITANT

HS Code 

2924297099

Toxicity

mouse,LD50,intravenous,320mg/kg (320mg/kg),U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#01183,

MSDS

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3-Amino-4-methoxybenzanilide Usage And Synthesis

Chemical Properties

Gray powder.

Uses

3-Amino-4-methoxybenzanilide is used in preparation method of Cyanate resin-based near-zero expansion composite material truss rod.

Uses

Dyes, pharmaceuticals, and other organic chemicals.

Synthesis

3-Amino-4-methoxybenzanilide is prepared by the reaction of 3-amino-4-methoxybenzoic acid and aniline. The steps are as follows:
A total of 0.17 mL (0.18 mmol) of DIC and 0.24 g (0.18 mmol) of HOBt were added to a dichloromethane solution of 0.20 g (0.12 mmol) of 1 at room temperature, and the reaction mixture was stirred for 0.5 h. Then, 0.13 mL (0.14 mmol) of aniline was added to the mixture. After approximately 3 h, 0.5 N NaOH was added to the solution. The lower layer was isolated, and 0.5 N HCl was added until the aqueous solution was neutral. The dichloromethane layer was washed three times with 10 mL of water, and then MgSO4 was added. After 2 h, the solution was filtered, and the solvent was removed. The residue was purified by column chromatography on silica gel (eluent: petroleum ether:ethyl acetate = 3:1) to yield the desired 3-Amino-4-methoxybenzanilide as a white solid (yield: 76%). Mp: 197-198 °C. 1H NMR (400 MHz, DMSO-d6) δ (ppm): 9.92 (1H, s, NH), 7.74 (2H, d, J = 9.0 Hz, PhH), 7.32 (2H, m, PhH), 7.21 (2H, d, J = 8.0 Hz, PhH), 7.06 (1H, m, PhH), 6.88 (1H, d, J = 8.0 Hz, PhH), 4.90 (2H, br s, NH2), 3.83 (3H, s, OCH3). ESI-MS (m/z): 243 (M + H)+.

3-Amino-4-methoxybenzanilide(120-35-4)Related Product Information

• N,N-Dimethyl-1,4-phenylenediamine
• (Trifluoromethoxy)benzene
• ALTRENOGEST
• p-Anisidine
• 2-Aminophenol
• 2-(Trifluoromethoxy)aniline
• Benzamide
• 4'-Methoxyacetophenone
• p-Anisaldehyde
• Tris(hydroxymethyl)aminomethane
• 4-Methoxybenzoic acid
• Glycine
• BENZANILIDE
• 4-Methoxyphenylacetone
• 4-(Trifluoromethoxy)aniline
• Anisole
• p-Aminobenzamide
• Chlorantraniliprole