Basic information Safety Supplier Related

N-(3-Bromo-4-methylphenyl)-4-(4-pyridinylmethyl)-1-phthalazinamine

Basic information Safety Supplier Related

N-(3-Bromo-4-methylphenyl)-4-(4-pyridinylmethyl)-1-phthalazinamine Basic information

Product Name:
N-(3-Bromo-4-methylphenyl)-4-(4-pyridinylmethyl)-1-phthalazinamine
Synonyms:
  • ACC-789; ZK-202650; NVP-ACC-789;ACC789;ACC 789
  • N-(3-Bromo-4-methylphenyl)-4-(4-pyridinylmethyl)-1-phthalazinamine
  • Acc-789
  • ZK 202650
  • NVP-ACC-789
  • ACC-789 (NVP-ACC789)
  • N-(3-Bromo-4-methylphenyl)-4-(pyridin-4-ylmethyl)phthalazin-1-amine
  • NVP ACC789,Platelet-derived growth factor receptor,inhibit,ZK 202650,PDGFR,NVPACC789,Inhibitor,ZK-202650,ACC789,NVP-ACC789,VEGFR,ACC 789,NVP-ACC-789,Vascular endothelial growth factor receptor
CAS:
300842-64-2
MF:
C21H17BrN4
MW:
405.29
Mol File:
300842-64-2.mol
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N-(3-Bromo-4-methylphenyl)-4-(4-pyridinylmethyl)-1-phthalazinamine Chemical Properties

Boiling point:
607.7±55.0 °C(Predicted)
Density 
1.441
storage temp. 
Store at -20°C
solubility 
DMSO:13.0(Max Conc. mg/mL);32.08(Max Conc. mM)
DMF:0.5(Max Conc. mg/mL);1.23(Max Conc. mM)
DMF:PBS (pH 7) (1:10):0.09(Max Conc. mg/mL);0.22(Max Conc. mM)
Ethanol:0.2(Max Conc. mg/mL);0.49(Max Conc. mM)
form 
A crystalline solid
pka
5.46±0.10(Predicted)
color 
Light yellow to yellow
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N-(3-Bromo-4-methylphenyl)-4-(4-pyridinylmethyl)-1-phthalazinamine Usage And Synthesis

Uses

NVP-ACC789, is an inhibitor of human VEGFR-1, VEGFR-2 (mouse VEGFR-2), VEGFR-3 and PDGFR-β with IC50s of 0.38, 0.02 (0.23), 0.18, 1.4 μM, respectively.

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