(2E)-3-(Dimethylamino)-1-(3-pyridyl)prop-2-en-1-one Chemical Properties

Melting point:

113℃

Boiling point:

281℃

Density 

1.070

Flash point:

124℃

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

solubility 

Acetonitrile (Slightly), Chloroform (Slightly), Methanol (Slightly)

form 

Solid

pka

4.74±0.70(Predicted)

color 

Dark Brown to Very Dark Brown

(2E)-3-(Dimethylamino)-1-(3-pyridyl)prop-2-en-1-one Usage And Synthesis

Description

(2E)-3-(Dimethylamino)-1-(3-pyridyl)prop-2-en-1-one is a pharmaceutical intermediate used as an intermediate of nilotinib, a targeted anticancer drug for the treatment of chronic myeloid leukaemia (CML).

Uses

(2E)-3-(Dimethylamino)-1-(3-pyridyl)prop-2-en-1-one acts as a reagent for the synthesis of oxindole-linked indolyl-pyrimidine derivatives which are potential cytotoxic agents.

Solubility in organics

(2E)-3-(Dimethylamino)-1-(3-pyridyl)prop-2-en-1-one is soluble in chloroform and dichloromethane.

(2E)-3-(Dimethylamino)-1-(3-pyridyl)prop-2-en-1-one(123367-26-0)Related Product Information

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