3,3`-Dithiobispropanoic acid bis(N-hydroxysucciniMde ester)
3,3`-Dithiobispropanoic acid bis(N-hydroxysucciniMde ester) Basic information
- Product Name:
- 3,3`-Dithiobispropanoic acid bis(N-hydroxysucciniMde ester)
- Synonyms:
-
- 3,3'-dithiopropionic acid bis(N-hydroxysuccinimide ester)
- Di(N-succinimidyl) 3,3μ-dithiodipropionate, Dithiobis(succinimidyl propionate), DTSP, Lomants reagent
- 3,3'-DITHIODIPROPIONIC ACID BIS(N-SUCCINIMIDYL ESTER)
- 3,3'-DITHIO-BIS(PROPIONIC ACID N-HYDROXYSUCCINIMIDE ESTER)
- 3,3'-DITHIOBIS(SUCCINIMIDYL PROPIONATE)
- 3,3'-DITHIOPROPIONIC ACID DI(N-SUCCINIMIDYL ESTER)
- 3,3'-DITHIODIPROPIONIC ACID DI-(N-HYDROXY-SUCCINIMIDE ESTER)
- 3,3'-DITHIODIPROPIONIC ACID DI(N-SUCCINIMIDYL ESTER)
- CAS:
- 57757-57-0
- MF:
- C14H16N2O8S2
- MW:
- 404.42
- EINECS:
- 260-931-5
- Product Categories:
-
- N-Substituted Maleimides, Succinimides & Phthalimides
- Heterocycles
- N-Substituted Succinimides
- Sulfur & Selenium Compounds
- Homobifunctional Crosslinker
- homoXlink
- ADC LINKER
- Mol File:
- 57757-57-0.mol
3,3`-Dithiobispropanoic acid bis(N-hydroxysucciniMde ester) Chemical Properties
- Melting point:
- 128-133 °C
- Boiling point:
- 560.1±60.0 °C(Predicted)
- Density
- 1.57±0.1 g/cm3(Predicted)
- storage temp.
- -20°C
- solubility
- chloroform: 50 mg/mL
- form
- powder
- color
- Off-White
- BRN
- 1518074
- CAS DataBase Reference
- 57757-57-0(CAS DataBase Reference)
MSDS
- Language:English Provider:SigmaAldrich
3,3`-Dithiobispropanoic acid bis(N-hydroxysucciniMde ester) Usage And Synthesis
Description
DSP Crosslinker is a cleavable crosslinker. It contains two terminal NHS ester moieties which can react with primary amines. The disulfide bonds can be cleaved via a reduction reaction using Dithiothreitol (DTT) reagent.
Chemical Properties
Off-White Solid
Uses
3,3′-Dithiodipropionic acid di(N-hydroxysuccinimide ester) (DSP) has been used as a protein cross-linker.
Uses
3,3`-Dithiobispropanoic acid bis(N-hydroxysucciniMde ester) can be used in the crosslinking of intracellular proteins prior to cell lysis.
Uses
3,3`-Dithiobispropanoic acid bis(N-hydroxysucciniMde ester) can be used as amine reactive homobifunctional cross-linking reagent, cleavable under mild conditions with hydroxylamine (pH 8.5, 3-6 h, 37oC)
General Description
3,3′-Dithiodipropionic acid di(N-hydroxysuccinimide ester) (DSP) is a homobifunctional cross-linking reagent containing a cleavable disulfide linkage. It is typically coupled to molecules containing primary amines by amide bonds buffered at pH 7.5 (6.5-8.5).
3,3`-Dithiobispropanoic acid bis(N-hydroxysucciniMde ester)Supplier
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3,3`-Dithiobispropanoic acid bis(N-hydroxysucciniMde ester)(57757-57-0)Related Product Information
- 3,3'-DITHIODIPROPIONIC ACID
- DISUCCINIMIDYL SUBERATE
- BOC-MET-OSU
- DI(N-SUCCINIMIDYL) OXALATE
- 1,3-Benzenedicarboxylic acid, 1,3-bis(2,5-dioxo-1-pyrrolidinyl) ester
- 2,5-Pyrrolidinedione, 1,1'-[1,4-phenylenebis(carbonyloxy)]bis-
- N-Iodosuccinimide
- Dilauryl thiodipropionate
- DST
- EGS Crosslinker
- ETHYLENE GLYCOL DISUCCINATE BIS(SULFO-N-
- DISULFOSUCCINIMIDYL TARTRATE
- N-Hydroxysuccinimide
- Succinimide
- 3,3'-Thiodipropionic acid
- 3,3`-Dithiobispropanoic acid bis(N-hydroxysucciniMde ester)
- 3,3'-Dithiobis(sulfosuccinimidylpropionate)
- (Fmoc-Cys-OSu)2, (Disulfide bond)