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YK-4-279

Basic information Safety Supplier Related

YK-4-279 Basic information

Product Name:
YK-4-279
Synonyms:
  • YK-4-279
  • 4,7-Dichloro-1,3-dihydro-3-hydroxy-3-[2-(4-methoxyphenyl)-2-oxoethyl]-2H-indol-2-one
  • 4,7-Dichloro-1,3-dihydro-3-hydroxy-3-[2-(4-methoxyphenyl)-2-oxoethyl]-2H-indol-2-one YK-4-279
  • YK-4-279;YK 4-279
  • 4,7-dichloro-3-hydroxy-3-[2-(4-methoxyphenyl)-2-oxoethyl]-1H-indol-2-one
  • CS-1785
  • 2H-Indol-2-one, 4,7-dichloro-1,3-dihydro-3-hydroxy-3-[2-(4-methoxyphenyl)-2-oxoethyl]-
  • YK-4-279 USP/EP/BP
CAS:
1037184-44-3
MF:
C17H13Cl2NO4
MW:
366.2
Product Categories:
  • Inhibitors
Mol File:
1037184-44-3.mol
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YK-4-279 Chemical Properties

Melting point:
149-151℃
Boiling point:
608.9±55.0 °C(Predicted)
Density 
1.456
storage temp. 
Store at -20° C.
pka
10.43±0.20(Predicted)
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YK-4-279 Usage And Synthesis

Chemical Properties

A crystalline solid

Uses

YK-4-279 is a small molecule inhibitor of EWS-FLI1 protein, and has been shown to disrupt the mitotic progression of neuroblastoma cells, and potentially other cancers.

Uses

An oncogenic fusion protein found in Ewing's sarcoma, a family of undifferentiated tumors which occur throughout the body. The binding of ES-FLI1 to RNA helicase A (RHA) promotes its oncogenic function. Inhibits protein-protein interactions between ES-FLI1 and RHA. At 10 μM, YK-4-279 blocks RHA binding to ES-FLI1 and induces apoptosis of a panel of Ewing's sarcoma tumor cell lines with IC50 values ranging from 0.5 to 2 μM.1 At 1.5 mg per dose, YK-4-279 reduces the growth of Ewing's sarcoma orthotopic xenografts in mice after treatment with the inhibitor for two weeks.

YK-4-279Supplier

Shanghai Boyle Chemical Co., Ltd.
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sales@boylechem.com
3B Pharmachem (Wuhan) International Co.,Ltd.
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821-50328103-801 18930552037
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3bsc@sina.com
Chembest Research Laboratories Limited
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021-20908456
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sales@BioChemBest.com
Dalian Meilun Biotech Co., Ltd.
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0411-62910999 13889544652
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sales@meilune.com
Wuhan TCASChem Technology Co., Ltd.
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027-86697669 13986148687
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947257336@qq.com