AT-56 Chemical Properties

Boiling point:

620.4±65.0 °C(Predicted)

Density 

1.216±0.06 g/cm3(Predicted)

storage temp. 

Inert atmosphere,Store in freezer, under -20°C

solubility 

DMSO: soluble10mg/mL, clear

form 

powder

pka

4.99±0.10(Predicted)

color 

white to beige

InChIKey

LQNGMDUIRLSESZ-UHFFFAOYSA-N

SMILES

N1(CCCCC2=NNN=N2)CC/C(=C2/C3=CC=CC=C3C=CC3=CC=CC=C3/2)/CC1

Safety Information

WGK Germany 

3

AT-56 Usage And Synthesis

Uses

AT-56 is an orally active inhibitor of Lipocalin-type prostaglandin D synthase.

in vitro

AT-56 (1-30 μM; 10 minutes) dose-dependently inhibits the production of PGD2 in L-PGDS-expressing human medulloblastoma TE-671 cells with an IC50 of about 3 μM.

in vivo

AT-56 (1-30 mg/kg; p.o.) suppresses the PGD2 production in the stab-wounded brain.
AT-56 (1-10 mg/kg; p.o.) suppresses the L-PGDS-mediated allergic airway inflammation in mice.
AT-56 (10 mg/kg; p.o.) exhibits Cmax (2.15 μg/ml), half-life (1.71 h) and high oral bioavailability (82%).

storage

Store at -20°C