Momordicoside G
Momordicoside G Basic information
- Product Name:
- Momordicoside G
- Synonyms:
-
- Momordicoside G
- Momordicacoside G
- Momordica charantia saponin G
- β-D-Allopyranoside, (3S,5R,8S,9S,10S,13R,14S,17R)-1,3,4,8,10,11,12,13,14,15,16,17-dodecahydro-17-[(1R,3E)-5-methoxy-1,5-dimethyl-3-hexenyl]-4,4,13,14-tetramethyl-5,9-(epoxymethano)-2H-cyclopenta[a]phenanthren-3-yl
- CAS:
- 81371-54-2
- MF:
- C37H60O8
- MW:
- 632.88
- EINECS:
- 200-258-5
- Mol File:
- 81371-54-2.mol
Momordicoside G Chemical Properties
- Boiling point:
- 711.4±60.0 °C(Predicted)
- Density
- 1.20±0.1 g/cm3(Predicted)
- solubility
- Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
- form
- Powder
- pka
- 12.91±0.70(Predicted)
Momordicoside G Usage And Synthesis
Uses
Momordicoside G can be used to regulate macrophage phenotypes to stimulate lung injury repair, as well as, prevent urethane-induced lung carcinoma lesions. It can also be used for anti-diabetic and anti-inflammatory effects.
Definition
ChEBI: Momordicoside G is a glycoside and a cucurbitacin.
in vivo
Lung carcinogenic model in ICR mice is induced by Urethane (HY-B1207) (600 mg/kg; i.p.; once weekly for 4 or 8 weeks), or in in macrophage-competent and macrophage-deleted mice is induced by LPS (HY-D1056) (2 mg/kg; intratracheal method) with 4 mg/mouse IEC (i.p.)[1].
Momordicoside G (50 mg/kg; p.o.; once daily for 4 or 8 weeks) prevents urethane-induced lung injury and carcinoma lesions in mouse lung carcinogenic model[1].
Momordicoside G (50 mg/kg; p.o.; once daily for 2 weeks) promotes lung injury repair in LPS-induced lung injury model[1].
| Animal Model: | Mouse lung carcinogenic model: Urethane-induced lung carcinogenic model and LPS-induced lung injury model[1] |
| Dosage: | 50 mg/kg |
| Administration: | Oral gavage; once daily for 4 or 8 weeks |
| Result: | Affected inflammasome and cytokines during urethane-induced lung injury and carcinoma lesions. Exhibits macrophage-regulating capacity in LPS-induced lung injury model. |
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