Basic information Safety Supplier Related

SC-1

Basic information Safety Supplier Related

SC-1 Basic information

Product Name:
SC-1
Synonyms:
  • SC-1
  • N-[4-Chloro-3-(trifluoromethyl)phenyl]-N′-[4-(4-cyanophenoxy)phenyl]-urea
  • Urea, N-[4-chloro-3-(trifluoromethyl)phenyl]-N'-[4-(4-cyanophenoxy)phenyl]-
  • SC-1 >=98% (HPLC)
  • 1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-(4-(4-cyanophenoxy)phenyl)urea
  • STAT,cyclin-D1,Inhibitor,inhibit,kinase,Apoptosis,1(4Chloro3(trifluoromethyl)phenyl)3(4(4cyanophenoxy)phenyl)urea,p-STAT3,orally,anticancer,SHP-1,1 (4 Chloro 3 (trifluoromethyl)phenyl) 3 (4 (4 cyanophenoxy)phenyl)urea,survivin
  • Compound SC-1
  • 1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-(4-(4-cyanophenoxy)phenyl)urea, 10 mM in DMSO
CAS:
1313019-65-6
MF:
C21H13ClF3N3O2
MW:
431.8
EINECS:
806-020-3
Mol File:
1313019-65-6.mol
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SC-1 Chemical Properties

storage temp. 
2-8°C
solubility 
DMSO: soluble15mg/mL, clear
form 
powder
color 
white to beige
Water Solubility 
Water: Insoluble
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Safety Information

Hazard Codes 
Xi
Risk Statements 
36
Safety Statements 
26
WGK Germany 
3
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SC-1 Usage And Synthesis

Biological Activity

SC-1 is a derivative of the multiple tyrosine kinase inhibitor sorafenib with no kinase-inhibition activity. SC-1 blocks STAT3 phosphorylation and activation with similar potency to sorafenib, and induces apoptosis in hepatocellular carcinoma cell lines.

SC-1Supplier

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