SC-1
SC-1 Basic information
- Product Name:
- SC-1
- Synonyms:
-
- SC-1
- N-[4-Chloro-3-(trifluoromethyl)phenyl]-N′-[4-(4-cyanophenoxy)phenyl]-urea
- Urea, N-[4-chloro-3-(trifluoromethyl)phenyl]-N'-[4-(4-cyanophenoxy)phenyl]-
- SC-1 >=98% (HPLC)
- 1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-(4-(4-cyanophenoxy)phenyl)urea
- STAT,cyclin-D1,Inhibitor,inhibit,kinase,Apoptosis,1(4Chloro3(trifluoromethyl)phenyl)3(4(4cyanophenoxy)phenyl)urea,p-STAT3,orally,anticancer,SHP-1,1 (4 Chloro 3 (trifluoromethyl)phenyl) 3 (4 (4 cyanophenoxy)phenyl)urea,survivin
- Compound SC-1
- 1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-(4-(4-cyanophenoxy)phenyl)urea, 10 mM in DMSO
- CAS:
- 1313019-65-6
- MF:
- C21H13ClF3N3O2
- MW:
- 431.8
- EINECS:
- 806-020-3
- Mol File:
- 1313019-65-6.mol
SC-1 Chemical Properties
- storage temp.
- 2-8°C
- solubility
- DMSO: soluble15mg/mL, clear
- form
- powder
- color
- white to beige
- Water Solubility
- Water: Insoluble
SC-1 Usage And Synthesis
Uses
STAT3-IN-7 is a Sorafenib analogue and potently inhibits the phosphorylation of STAT3. STAT3-IN-7 induces cell apoptosis through SHP-1 dependent STAT3 inactivation. STAT3-IN-7 does not inhibit kinase activity and has anticancer effects[1].
Biological Activity
SC-1 is a derivative of the multiple tyrosine kinase inhibitor sorafenib with no kinase-inhibition activity. SC-1 blocks STAT3 phosphorylation and activation with similar potency to sorafenib, and induces apoptosis in hepatocellular carcinoma cell lines.
in vivo
STAT3-IN-7 (10 mg/kg; oral gavage; daily; for 28 days; female NCr athymic nude mice) treatment shows efficacious antitumor activity and p-STAT3 downregulation in MDA-MB-468 xenograft tumors[1].
| Animal Model: | Female NCr athymic nude mice (4-6 weeks of age) injected with breast cancer cells [1] |
| Dosage: | 10 mg/kg |
| Administration: | Oral gavage; daily; for 28 days |
| Result: | Showed efficacious antitumor activity and p-STAT3 downregulation in MDA-MB-468 xenograft tumors. |
IC 50
p-STAT3
References
[1] Chun-Yu Liu, et al. Novel sorafenib analogues induce apoptosis through SHP-1 dependent STAT3 inactivation in human breast cancer cells. Breast Cancer Res. 2013;15(4):R63. DOI:10.1186/bcr3457
SC-1Supplier
- Tel
- sales@boylechem.com
- Tel
- 1-631-485-4226; 16314854226
- info@bocsci.com
- Tel
- 021-61312847; 18021002903
- 3008007409@qq.com
- Tel
- 177-54423994 17754423994
- 2853530910@QQ.com
- Tel
- 021-QQ：65489617 15618227136
- Sales@ATKchemical.com