ChemicalBook > Product Catalog > Biochemical Engineering > Inhibitors > Microbiology > Integrase Inhibitors > BMS707035
BMS707035
BMS707035 Basic information
- Product Name:
- BMS707035
- Synonyms:
-
- BMS707035
- CS-455
- BMS 707035;BMS707035
- 2-(1,1-DIOXOTHIAZINAN-2-YL)-N-[(4-FLUOROPHENYL)METHYL]-5-HYDROXY-1-METHYL-6-OXOPYRIMIDINE-4-CARBOXAMIDE
- N-[(4-Fluorophenyl)methyl]-1,6-dihydro-5-hydroxy-1-methyl-6-oxo-2-(tetrahydro-1,1-dioxido-2H-1,2-thiazin-2-yl)-4-pyrimidinecarboxamide
- 4-Pyrimidinecarboxamide, N-[(4-fluorophenyl)methyl]-1,6-dihydro-5-hydroxy-1-methyl-6-oxo-2-(tetrahydro-1,1-dioxido-2H-1,2-thiazin
- 4-Pyrimidinecarboxamide, N-[(4-fluorophenyl)methyl]-1,6-dihydro-5-hydroxy-1-methyl-6-oxo-2-(tetrahydro-1,1-dioxido-2H-1,2-thiazin-2-yl)-
- BMS707035 USP/EP/BP
- CAS:
- 729607-74-3
- MF:
- C17H19FN4O5S
- MW:
- 410.42
- Product Categories:
-
- Inhibitors
- Inhibitor
- Mol File:
- 729607-74-3.mol
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BMS707035 Chemical Properties
- Density
- 1.54
- storage temp.
- Store at -20°C
- solubility
- insoluble in EtOH; insoluble in H2O; ≥41 mg/mL in DMSO
- form
- Powder
- pka
- 4.50±1.00(Predicted)
- color
- Off-white to pink
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BMS707035 Usage And Synthesis
Uses
BMS-707035 is a specific HIV-I integrase (IN) inhibitor.
in vivo
BMS-707035 has a low clearance effect in the rat, dog and monkey with moderate to long elimination half-lives in all species[1].
Pharmacokinetic Parameters of BMS-707035 in rat, dog and monkey (IV)[1].
| Rat | Monkey | Dog | |
| IV dose (mg/kg) | 0.87 | 1 | 1 |
| CL (ml/min/kg) | 9.7 | 6.8 | 2.0 |
| T1/2(h) | 4.0 | 6.5 | 6.0 |
| Vss(L/kg) | 0.86 | 0.87 | 0.45 |
| PO dose (mg/kg) | 4.4 | 5 | 5.2 |
| Cmax(μM) | 4.51 | 6.12 | 72.8 |
| tmax(h) | 0.25 | 0.25 | 0.25 |
| AUC (μM*h) | 19.1 | 19.2 | 162 |
| F (%) | 86 | 56 | 129 |
target
HIV-I integrase
BMS707035Supplier
Shanghai Boyle Chemical Co., Ltd.
- Tel
- sales@boylechem.com
Shanghai Paulshine Chemical Co., Ltd.
- Tel
- +86-021-37788663
BOC Sciences
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- 1-631-485-4226; 16314854226
- info@bocsci.com
Dalian Meilun Biotech Co., Ltd.
- Tel
- 0411-62910999 13889544652
- sales@meilune.com
Shanghai civi chemical technology co.,Ltd
- Tel
- 86-21-34053660
- sale@labgogo.com