FMoc-NH-8(ethylene glycol)-acetic acid Chemical Properties

Boiling point:

773.7±60.0 °C(Predicted)

Density 

1.201±0.06 g/cm3(Predicted)

storage temp. 

-20°C, protect from light

solubility 

DMSO : 100 mg/mL (153.91 mM; Need ultrasonic)

form 

Oil

pka

3.39±0.10(Predicted)

color 

Light yellow to brown

InChIKey

JRLUSGRARXJCNA-UHFFFAOYSA-N

SMILES

C(OCC1C2=C(C=CC=C2)C2=C1C=CC=C2)(=O)NCCOCCOCCOCCOCCOCCOCCOCCOCC(O)=O

Safety Information

HS Code 

2942000090

FMoc-NH-8(ethylene glycol)-acetic acid Usage And Synthesis

Description

Fmoc-NH-PEG8-CH2COOH is a PEG linker containing an Fmoc-protected amine and a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The Fmoc group can be deprotected under basic condition to obtain the free amine which can be used for further conjugations. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.

Uses

Fmoc-NH-PEG8-CH2COOH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Fmoc-NH-PEG8-CH2COOH is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC 50

Cleavable Linker; PEGs; Alkyl/ether

References

[1] Michael A, et al. Synthesis of Bifunctional Integrin‐Binding Peptides Containing PEG Spacers of Defined Length for Non‐Viral Gene Delivery. Volume2008, Issue17.

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