H2N-PEG4-Propyne Chemical Properties

Boiling point:

315.9±32.0 °C(Predicted)

Density 

1.037±0.06 g/cm3(Predicted)

storage temp. 

-20°C

solubility 

Soluble in DMSO, DMF, DCM, THF, or chloroform.

form 

Solid

pka

8.74±0.10(Predicted)

color 

Pale Yellow

Appearance

Colorless or light yellow oil

Safety Information

WGK Germany 

3

H2N-PEG4-Propyne Usage And Synthesis

Description

Propargyl-PEG4-amine has a propargyl group and an amine group. The amine group is reactive with carboxylic acids, activated NHS esters, carbonyls, etc. The propargyl group can form triazole linkage with azide-bearing biomolecules.

Uses

1-Amino-3,6,9,12-tetraoxapentadec-14-yne is used as a acetylene containing reagent with PEG spacer and carboxyl reactivity. The hydrophilic PEG spacer adds to the water solubility of this reagent, allowing for easy modification of carboxylic acid containing biomolecules such as antibodies, proteins and peptides with the terminal alkyne. The PEG spacer also reduces aggregation of modified proteins stored in solution by adding hydrophilic character.

reaction suitability

reaction type: click chemistry
reagent type: cross-linking reagent

IC 50

PEGs

H2N-PEG4-Propyne(1013921-36-2)Related Product Information

• Azido-PEG4-NHS Ester
• Thiol-dPEG5-azido
• H2N-PEG2-Propyne
• H2N-PEG11-OH
• Propargyl-PEG4-t-butyl ester
• Propargyl-PEG4-N3
• Propargyl-PEG9-amine
• Propargyl-PEG6-amine
• Propargyl-PEG4-acid
• Propargyl-PEG5-amine
• 2-(2-Propynyloxy)ethylamine
• Proparyl-PEG5-methane
• Propargyl-PEG3-amine
• propargyl-PEG3-Acid
• MPEG3-Propyne
• Propargyl-PEG8-amine
• Alkyne-PEGn-NH2 2K, 5K, 10K, 20K
• Propargyl-PEG4-NHS ester