alpha, oMega-Dipropionic acid triethylene glycol Chemical Properties

Boiling point:

483.7±45.0 °C(Predicted)

Density 

1.219±0.06 g/cm3(Predicted)

storage temp. 

Sealed in dry,Room Temperature

solubility 

Soluble in Water, DMSO, DCM, DMF

form 

Oil

pka

3.97±0.10(Predicted)

color 

Colorless to off-white

Safety Information

HS Code 

2918999090

alpha, oMega-Dipropionic acid triethylene glycol Usage And Synthesis

Description

Bis-PEG4-acid is a PEG linker containing two terminal carboxylic acid groups. The hydrophilic PEG spacer increases solubility in aqueous media. The terminal carboxylic acids can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.

Uses

Bis-PEG4-acid is a PEG PROTAC linker.

IC 50

PEGs

References

[1] Maniaci C, et al. Homo-PROTACs: bivalent small-molecule dimerizers of the VHL E3 ubiquitin ligase to induce self-degradation. Nat Commun. 2017 Oct 10;8(1):830. DOI:10.1038/s41467-017-00954-1

alpha, oMega-Dipropionic acid triethylene glycol(31127-85-2)Related Product Information

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