Isoescin IB Chemical Properties

Boiling point:

1148.1±65.0 °C(Predicted)

Density 

1.46

solubility 

Soluble in methanol;

pka

2.63±0.70(Predicted)

form 

powder

color 

White

Water Solubility 

slightly soluble in water

Isoescin IB Usage And Synthesis

Chemical Properties

The saponins found in escin exist in two forms, β-escin and α-escin, which can be distinguished by melting point, hemolytic index, specific rotation and solubility in water. β-Escin (mainly consisting of escin Ia and escin Ib) is the major active ingredient in horse chestnut seeds extracts.

Pharmacological Action

Escin exhibits remarkable anti-inflammatory, anti-edematous and vasoprotective properties in a dose-dependent manner which are quite evident at 10-6–10-7 M. Escin has been traditionally used to treat conditions such as chronic venous insufficiency, hemorrhoids, inflammation and cerebral ischemic damage.

Escin Ia & Isoescin Ib

As the minor component of escin, α-escin (mainly consisting of isoescin Ia and isoescin Ib) exhibits lower bioactivity. Similar to isoescin Ia is the isomer of escin Ia, Isoescin Ib is an isomer of escin Ib. Both of them were found to be isomerizable in vitro. Escin Ib and isoescin Ib exhibits stronger pharmacological activity than escin Ia and isoescin Ia. As the result, pharmacokinetics study of them would be helpful for improving the practice of escin application.

Isoescin IB(219944-46-4)Related Product Information

• Escin
• escin IIa
• GYPENOSIDE-XVII
• Gypenoside XLVI
• AESCIN IB(SH)
• Escin, monosodium salt
• salviaflaside
• Isoescin Ie
• Isoastragaloside IV
• Isoginsenoside Rh3
• isocucurbitacin B
• Ginsenoside Rg3
• Notoginsenoside R1
• Ginsengrootextract
• AESCIN IA(SH)
• (3beta,4beta,16alpha,21beta,22alpha)-28-(Acetyloxy)-16,22,23-trihydroxy-21-[[(2E)-2-methyl-1-oxo-2-buten-1-yl]oxy]olean-12-en-3-yl O-beta-D-glucopyranosyl-(1-2)-O-[beta-D-glucopyranosyl-(1-4)]-beta-D-glucopyranosiduronic acid
• Escin Ie
• ESCIN IIB