Glycine, L-g-glutaMyl-S-(phenylMethyl)-L-cysteinyl-2-phenyl-,1,3-diethyl ester, (2R)- Chemical Properties

Melting point:

>94°C (dec.)

Boiling point:

749.7±60.0 °C(Predicted)

Density 

1.216±0.06 g/cm3(Predicted)

storage temp. 

Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

solubility 

DMSO (Slightly), Methanol (Slightly)

pka

12?+-.0.46(Predicted)

form 

Solid

color 

White to Off-White

InChIKey

FXTMNDVNPLUYKX-OKIYALLLNA-N

SMILES

C(OCC)(=O)[C@@H](C1=CC=CC(CC)=C1)N(C(=O)CC[C@@H](C(O)=O)N)C(=O)[C@H](CSCC1=CC=CC=C1)N |&1:5,19,26,r|

Glycine, L-g-glutaMyl-S-(phenylMethyl)-L-cysteinyl-2-phenyl-,1,3-diethyl ester, (2R)- Usage And Synthesis

Description

Ezatiostat is an inhibitor of glutathione S-transferase pi 1-1 (GSTP1-1; K_i = 0.4 μM). It is selective for GSTP1-1 over GSTα and GSTμ family GSTs (K_is = 20-75 μM). Ezatiostat also inhibits the protein-protein interaction between GSTP1-1 and JNK1. In vivo, ezatiostat (75 mg/kg) increases the number of circulating white blood cells in Gstp1 wild-type, but not Gstp1^-/-, mice.

Uses

Ezatiostat is a tripeptide analog of glutathione that can selectively inhibit GSTP1-1, the most prevalent Glutathione S-transferases (GST) isozyme in nonhepatic tissues, catalytic activity with minimal effect on the related GSTα and -μ families.

in vivo

target

Gutathione S-transferase

References

[1] JACOB S. YOUNT  Howard C H  Mingzi M Zhang. Visualization and Identification of Fatty Acylated Proteins Using Chemical Reporters[J]. Current protocols in chemical biology, 2011, 3 2. DOI: 10.1002/9780470559277.ch100225

Glycine, L-g-glutaMyl-S-(phenylMethyl)-L-cysteinyl-2-phenyl-,1,3-diethyl ester, (2R)-(168682-53-9)Related Product Information

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