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Palonosetron

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Palonosetron Basic information

Product Name:
Palonosetron
Synonyms:
  • Palonosteron
  • RS 25233-198
  • PALMATINE(P)
  • (3AS)-2-(S)-1-AZABICYCLO[2,2,2]OCT-3-YL)-2,3,3A,4,5,6-HEXAHYDRO-1H-BENZ(D)ISOQUINOLIN-1-ONE
  • (S)-2-(1-Azabicyclo[2.2.2]oct-3-yl)-2,4,5,6-tetrahydro-1H-benz[de]isoquinolin-1-one
  • Unii-5D06587D6r
  • Palonosetron (3aS)-2-(3S)-1-Azabicyclo[2.2.2]oct-3-yl-2,3,3a,4,5,6-hexahydro-1H-benz[de]isoquinolin-1-one
  • (3AS)-2-[(3S)-1-AZABICYCLO[2.2.2]OCT-3-YL]-2,3,3A,4,5,6-HEXAHYDRO-1H-BENZ[DE]ISOQUINOLIN-1-ONE
CAS:
135729-56-5
MF:
C19H22N2O
MW:
294.39
Mol File:
135729-56-5.mol
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Palonosetron Chemical Properties

Boiling point:
511.0±50.0 °C(Predicted)
Density 
1.24
pka
9.77±0.33(Predicted)
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Palonosetron Usage And Synthesis

Uses

Palonosetron can be used to Anti-emetic; antinauseant.

brand name

Aloxi (Helsinn).

in vivo

In anesthetized rats, Dehydro Palonosetron (RS 42358-197), administered by the intravenous, intraduodenal or transdermal route, dose-dependently inhibited the Bezold-Jarisch reflex induced by 2-methyl 5-HT (ID50:0.05 μg/kg; i.v., 5.7 μg/kg; i.d., and 11.6 μg/chamber, respectively)[1].
Dehydro Palonosetron (RS 42358-197; 0.01 ng/kg-10 mg/kg; oral administration; once) disinhibits behaviour in the mouse suppressed by the aversive situation of the light/dark test box[2].

Animal Model:Male albino BKW mice (30-35 g)[2]
Dosage:0.01 ng/kg, 0.1 ng/kg, 1 ng/kg, 100 ng/kg, 1 μg/kg, 100 μg/kg, 1 mg/kg, 10 mg/kg
Administration: Oral administration; once
Result:Increased the proportion of time mice spent and the number of rearings and line crossings in the light area of the test chamber.

IC 50

5-HT3 Receptor

PalonosetronSupplier

Daicel Chiral Technologies (China)CO.,LTD
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021-50460086-9 15921403865
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Shanghai Holy Biohemdeviser Co., Ltd
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021-61551100
Chengdu DingDang Pharmaceutical Co., Ltd.
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028-86040038 13980902949;
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market@dingdangchem.com
Roark Standards
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0755-83552066 15986688328
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service@roarkstandards.com
Amatek Scientific Co. Ltd.
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0512-56316828
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info@amateksci.com
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