8-BroMo-2-chloro-6-fluoro-quinazoline Chemical Properties

Boiling point:

308.8±35.0 °C(Predicted)

Density 

1.836

storage temp. 

Inert atmosphere,Store in freezer, under -20°C

form 

Solid

pka

-1.75±0.30(Predicted)

Appearance

White to light brown Solid

Safety Information

HS Code 

2933599590

8-BroMo-2-chloro-6-fluoro-quinazoline Usage And Synthesis

Synthesis

Step 5. Synthesis of 8-bromo-2-chloro-6-fluoroquinazoline: 0.5 M of 8-bromo-6-fluoroquinazolin-2(1H)-one was suspended in phosphorochloridic acid chloride and heated to 110 °C in an oil bath. During the reaction, the suspension transformed to a brown solution within 20 min. The reaction was completed after 1 h as monitored by LCMS. Subsequently, the excess phosphorus trichloride was removed by distillation under reduced pressure. The residue was carefully poured into ice water and the pH was adjusted with aqueous sodium bicarbonate to 7. The reaction mixture was extracted with ethyl acetate, the organic phases were combined, washed sequentially with water and saturated brine, dried over anhydrous sodium sulfate, and concentrated under reduced pressure to afford the target compound 8-bromo-2-chloro-6-fluoroquinazoline in 89% yield. The product was characterized by electrospray mass spectrometry (ES/MS) with m/z of 261/263 (MH+).

References

[1] Patent: WO2007/117607, 2007, A2. Location in patent: Page/Page column 332
[2] Patent: EP3287463, 2018, A1. Location in patent: Paragraph 0203; 0212
[3] Patent: US2018/208604, 2018, A1. Location in patent: Paragraph 0510-0511

8-BroMo-2-chloro-6-fluoro-quinazoline(953039-63-9)Related Product Information

• 8-BROMO-2-CHLOROQUINAZOLINE
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• 8-BROMO-2-METHOXY-1,5-NAPHTHYRIDINE
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• 8-Bromo-3-iodoimidazo[1,2-a]pyrazine
• 8-BROMO-2H-ISOQUINOLIN-1-ONE
• 3-Quinolinamine,8-bromo-(9CI)
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• 8-BROMO-3,4-DIHYDRO-2H-BENZO[1,4]OXAZINE HYDROCHLORIDE
• 8-BROMOQUINOLIN-2-AMINE
• 8-Bromo-[1,2,4]triazolo[1,5-a]pyridin-2-ylamine
• 3-Bromoisatoic anhydride
• 8-BROMO-2,3,4,5-TETRAHYDRO-1H-PYRIDO[4,3-B]INDOLE
• 2(1H)-Quinolinone, 8-broMo-3,4-dihydro-
• 8-bromo-2-methyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole
• methyl 2-chloroquinazoline-8-carboxylate
• 7-bromo-2-chloroquinazolin-4-amine