2-(CHLOROMETHYL)-1,3-BENZOXAZOLE Chemical Properties

Boiling point:

75/0.15mm

Density 

1.316±0.06 g/cm3(Predicted)

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

pka

0.95±0.10(Predicted)

form 

liquid

color 

Clear, very pale yellow

Safety Information

Hazard Codes 

Xi

Risk Statements 

43

Safety Statements 

36/37

HazardClass 

IRRITANT

HS Code 

2934999090

2-(CHLOROMETHYL)-1,3-BENZOXAZOLE Usage And Synthesis

Synthesis

B. To a stirred suspension of o-aminophenol (365 mg, 3.35 mmol) in dichloromethane (7 mL) was added ethyl 2-chloroacetimidate hydrochloride (798 mg, 5.05 mmol) in one batch at 0 °C. After 1 hour and 25 minutes of reaction, the mixture was raised from 0°C to ambient temperature and stirring was continued overnight. After completion of the reaction, the mixture was filtered through diatomaceous earth and the filtrate was concentrated. The residue was purified by column chromatography (eluent: hexane/ethyl acetate, 7/3) to afford 2-chloromethyl-1,3-benzoxazole as a light-colored oil (533 mg, 95% yield).

References

[1] European Journal of Medicinal Chemistry, 2011, vol. 46, # 5, p. 1706 - 1712
[2] Patent: WO2008/110793, 2008, A1. Location in patent: Page/Page column 103-104
[3] Molecules, 2018, vol. 23, # 10,
[4] Journal of Medicinal Chemistry, 2012, vol. 55, # 7, p. 3066 - 3075
[5] Synthesis, 1979, p. 102 - 103

2-(CHLOROMETHYL)-1,3-BENZOXAZOLE(41014-43-1)Related Product Information

• 2-(CHLOROMETHYL)-1,3-BENZOXAZOLE
• METHYL 2-[2-(CHLOROMETHYL)-1,3-BENZOXAZOL-5-YL]ACETATE
• 2-(Chloromethyl)-5-methoxy-1,3-benzoxazole
• 2-(CHLOROMETHYL)-6-METHYL-1,3-BENZOXAZOLE
• 2-(CHLOROMETHYL)-4-NITRO-1,3-BENZOXAZOLE
• 2-(CHLOROMETHYL)-6-NITRO-1,3-BENZOXAZOLE
• 5-(TERT-BUTYL)-2-(CHLOROMETHYL)-1,3-BENZOXAZOLE
• METHYL 2-(CHLOROMETHYL)-1,3-BENZOXAZOLE-5-CARBOXYLATE
• 2-TRICHLOROMETHYL-BENZOOXAZOLE
• 2-(CHLOROMETHYL)-5-METHYL-1,3-BENZOXAZOLE
• 5-CHLORO-2-(CHLOROMETHYL)-1,3-BENZOXAZOLE
• 4-BROMO-2-(CHLOROMETHYL)-1,3-BENZOXAZOLE
• 5-bromo-2-(chloromethyl)-1,3-benzoxazole
• 2-(CHLOROMETHYL)-5-NITRO-1,3-BENZOXAZOLE
• METHYL 2-(CHLOROMETHYL)-1,3-BENZOXAZOLE-6-CARBOXYLATE
• 6-Chloro-2-chloromethylbenzooxazole
• 2-(chloromethyl)-1,3-benzoxazole-5-sulfonamide
• 6-chloro-2-(chloromethyl)-1,3-benzoxazole