LasMiditan Chemical Properties

Melting point:

255℃

Boiling point:

433.3±45.0 °C(Predicted)

Density 

1.351

storage temp. 

-20°C Freezer, Under inert atmosphere

solubility 

Chloroform (Slightly), DMSO (Slightly)

pka

9.91±0.70(Predicted)

form 

Solid

color 

White to Off-White

LasMiditan Usage And Synthesis

Description

Lasmiditan (Item No. 28369) is an analytical reference standard categorized as an agonist of the serotonin (5-HT) receptor subtype 5-HT_1F. Formulations containing lasmiditan have been used in the treatment of migraine headache. Lasmiditan has low abuse potential. Lasmiditan is regulated as a Schedule V compound in the United States. This product is intended for research and forensic applications.

Uses

Lasmiditan is used in diagnosing, treating and/or preventing periodontal disease and/or tooth loss.

Synthesis

synthesis route of LasMiditan

References

[1] DAVID L NELSON. Preclinical pharmacological profile of the selective 5-HT1F receptor agonist lasmiditan.[J]. ACS Applied Materials & Interfaces, 2010: 1159-1169. DOI: 10.1177/0333102410370873
[2] DARREN WILBRAHAM MBBS, PHD. Abuse Potential of Lasmiditan: A Phase 1 Randomized, Placebo- and Alprazolam-Controlled Crossover Study[J]. The Journal of Clinical Pharmacology, 2019, 60 4: 495-504. DOI: 10.1002/jcph.1543

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