ChemicalBook > Product Catalog > Biochemical Engineering > Biochemical Reagents > Agonist Inhibitors > UNC569
UNC569
UNC569 Basic information
- Product Name:
- UNC569
- Synonyms:
-
- UNC569
- 1H-Pyrazolo[3,4-d]pyrimidin-6-amine, 1-[(trans-4-aminocyclohexyl)methyl]-N-butyl-3-(4-fluorophenyl)-
- CS-2399
- UNC-569;UNC 569
- anti-oncogenic,Inhibitor,ATP-competitive,ALL,UNC-569,UNC569,Tyro3,AKT,TAM Receptor,ERK,Mer,inhibit,pyrazolopyrimidine,Axl
- 1-((trans-4-Aminocyclohexyl)methyl)-N-butyl-3-(4-fluorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-6-amine
- N-butyl-3-(4-fluorophenyl)-1-{[(1r,4r)-4-aminocyclohexyl]methyl}-1H-pyrazolo[3,4-d]pyrimidin-6-amine
- UNC569, 10 mM in DMSO
- CAS:
- 1350547-65-7
- MF:
- C22H29FN6
- MW:
- 396.5
- Mol File:
- 1350547-65-7.mol
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UNC569 Chemical Properties
- storage temp.
- Store at -20°C
- solubility
- DMF: 2.5 mg/ml; DMF:PBS (pH 7.2) (1:4): 0.2 mg/ml; DMSO: 0.2 mg/ml; Ethanol: 2 mg/ml
- form
- A crystalline solid
- color
- White to yellow
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UNC569 Usage And Synthesis
Uses
UNC 569 induces morphological changes in pigment epithelia and photoreceptor cells in retina through MerTK inhibition in mice. A specific MerTK inhibitor.
in vivo
The in vivo pharmacokinetic properties of UNC569 (3 mg/kg) are also assessed in mice via both intravenous (IV) and oral (PO) administration. UNC569 has low systemic clearance (19.5 mL/min/kg), high volume of distribution (Vss of 5.83 L/kg), and good oral bioavailability (57%)[1].
Leukemic zebrafish are treated continuously for 2 weeks by immersion in 4 μM UNC569. the result shows that UNC569 induces more than 50% reduction in tumor burden compared with vehicle- and mock-treated fish[2].
IC 50
Axl; Tyro3; Mer
UNC569Supplier
Chembest Research Laboratories Limited
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SHANGHAI FORTUNE CHEMICAL TECHNOLOGY CO., LTD
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Shanghai Lollane Biological Technology Co.,Ltd.
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- 021-52996696，15000506266 15000506266
Shanghai EFE Biological Technology Co., Ltd.
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parabiochem
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- sale@parabiochem.com