1H-Thieno[3,4-d]iMidazole-4-pentanaMide, hexahydro-2-oxo-N-2-propynyl-, (3aS,4S,6aR)- Chemical Properties

Melting point:

169-170 °C

Boiling point:

614.8±50.0 °C(Predicted)

Density 

1.185±0.06 g/cm3(Predicted)

solubility 

good in DMSO and DMF,

form 

Solid

pka

13.90±0.40(Predicted)

color 

White to off-white

Water Solubility 

low in water

1H-Thieno[3,4-d]iMidazole-4-pentanaMide, hexahydro-2-oxo-N-2-propynyl-, (3aS,4S,6aR)- Usage And Synthesis

Description

Biotin alkyne is a biotinylated compound that enables simple biotinylation of antibodies, proteins and any other azide-containing biomolecules. The alkyne group of this reagent can react with azide moiety in Cu(I)-catalyzed Click Chemistry reaction to form a stable triazole linkage.

Uses

Biotin alkyne is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Biotin alkyne is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

IC 50

PEGs

References

[1] Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-1014. DOI:10.1016/j.chembiol.2020.07.020

1H-Thieno[3,4-d]iMidazole-4-pentanaMide, hexahydro-2-oxo-N-2-propynyl-, (3aS,4S,6aR)-(773888-45-2)Related Product Information

• BIOTIN HPDP
• 1H-Thieno[3,4-d]iMidazole-4-pentanaMide, hexahydro-N-[2-(4-hydroxyphenyl)ethyl]-2-oxo-, (3aS,4S,6aR)-
• N-(3-Azidopropyl)biotinaMide
• (+)-BIOTIN-EPSILON-AMINOCAPROIC ACID
• 3-[2-N-(BIOTINYL)AMINOETHYLDITHIO]PROPANOIC ACID
• UV Cleavable Biotin-PEG2-Azide
• Biotin-PEG4-Methyltetrazine
• Acetylene-PEG4-biotin conjugate
• Biotin-PEG2-azide
• Biotin-PEG4-N3
• Biotin-PEG₄-Azide
• Biotin-PEG2-C4-Alkyne
• DBCO-PEG4-biotin
• (3aS,4S,6aR)-Hexahydro-2-oxo-N-(15-oxo-3,6,9,12-tetraoxa-16-azanonadec-18-yn-1-yl)-1H-thieno[3,4-d]imidazole-4-pentanamide
• Azide-SS-biotin
• (4E)-TCO-PEG4-biotin
• Biotin-PEG4- Picolyl Azide
• EZ-LINK (TM) PFP-BIOTIN, 50 MG