Valsartan D9
Valsartan D9 Basic information
- Product Name:
- Valsartan D9
- Synonyms:
-
- L-Valine, N-(1-oxopentyl-d9)-N-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]Methyl]-
- ACWBQPMHZXGDFX-KDDXQTGLSA-N
- (2S)-3-methyl-2-[2,2,3,3,4,4,5,5,5-nonadeuteriopentanoyl-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]amino]butanoic acid
- rac-Valsartan D9
- [2H9]-Valsartan (mixture)
- [2H9]-Valsartan
- VALSARTAN-D9 (D7-D9 MIXTURE)
- Valsartan D9Q: What is Valsartan D9 Q: What is the CAS Number of Valsartan D9 Q: What is the storage condition of Valsartan D9 Q: What are the applications of Valsartan D9
- CAS:
- 1089736-73-1
- MF:
- C24H29N5O3
- MW:
- 435.53
- Mol File:
- 1089736-73-1.mol
Valsartan D9 Chemical Properties
- storage temp.
- Store at -20°C
- solubility
- DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 30 mg/ml
- form
- A solid
- color
- White to yellow
Valsartan D9 Usage And Synthesis
Chemical Properties
White Solid
Uses
An isotopically labelled version of Valsartan (V095750), a nonpeptide angiotensin II AT1-receptor antagonist. Antihypertensive.
Biological Activity
Valsartan-d9 is intended for use as an internal standard for the quantification of valsartan by GC- or LC-MS. Valsartan is a nonpeptide antagonist of the angiotensin II type 1 (AT1) receptor (IC50 = 2.7 nM). It is 20,000-fold selective for AT1 over AT2 and, unlike some other AT receptor antagonists, does not alter peroxisome proliferator-activated receptor γ (PPARγ) activity in vitro. In vivo, valsartan (30 mg/kg) increases cardiac output and reduces left ventricular fibrosis in a model of heart failure with reduced ejection fraction in mice with streptozotocin-induced diabetes. Formulations containing valsartan have been used in the treatment of hypertension and heart failure.
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Valsartan D9(1089736-73-1)Related Product Information
- Valsartan Acid Isopropyl Ester
- Valsartan
- valsartan
- Valsartan-d8
- VALSARTAN-D3
- KAZCQVXZLKDFCA-NDEPHWFRSA-N
- Telmisartan Impurity 10
- BOC-D-4,4'-BIPHENYLALANINE
- 1426129-50-1 enantioMer
- (R,E)-ethyl 5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpent-2-enoate
- methyl N-valeryl-N-[(2'-cyanobiphenyl-4-yl)methyl]-L-valinate
- Valsartan Impurity 10
- N-[2’-(1H-tetrazol-5-yl)biphenyl-4-yl methyl]-N-Valeryl-(L)-Valine methyl ester
- Valsartan Impurity 12
- ethyl N-((2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)Methyl)-N-pentanoyl-L-valinate
- Valsartan Desvaleryl Impurity
- Valsartan n-Propyl
- 4-Bromomethyl-2-cyanobiphenyl