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Valsartan D9

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Valsartan D9 Basic information

Product Name:
Valsartan D9
Synonyms:
  • L-Valine, N-(1-oxopentyl-d9)-N-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]Methyl]-
  • ACWBQPMHZXGDFX-KDDXQTGLSA-N
  • (2S)-3-methyl-2-[2,2,3,3,4,4,5,5,5-nonadeuteriopentanoyl-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]amino]butanoic acid
  • rac-Valsartan D9
  • [2H9]-Valsartan (mixture)
  • [2H9]-Valsartan
  • VALSARTAN-D9 (D7-D9 MIXTURE)
  • Valsartan D9Q: What is Valsartan D9 Q: What is the CAS Number of Valsartan D9 Q: What is the storage condition of Valsartan D9 Q: What are the applications of Valsartan D9
CAS:
1089736-73-1
MF:
C24H29N5O3
MW:
435.53
Mol File:
1089736-73-1.mol
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Valsartan D9 Chemical Properties

storage temp. 
Store at -20°C
solubility 
DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 30 mg/ml
form 
A solid
color 
White to yellow
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Valsartan D9 Usage And Synthesis

Chemical Properties

White Solid

Uses

An isotopically labelled version of Valsartan (V095750), a nonpeptide angiotensin II AT1-receptor antagonist. Antihypertensive.

Biological Activity

Valsartan-d9 is intended for use as an internal standard for the quantification of valsartan by GC- or LC-MS. Valsartan is a nonpeptide antagonist of the angiotensin II type 1 (AT1) receptor (IC50 = 2.7 nM). It is 20,000-fold selective for AT1 over AT2 and, unlike some other AT receptor antagonists, does not alter peroxisome proliferator-activated receptor γ (PPARγ) activity in vitro. In vivo, valsartan (30 mg/kg) increases cardiac output and reduces left ventricular fibrosis in a model of heart failure with reduced ejection fraction in mice with streptozotocin-induced diabetes. Formulations containing valsartan have been used in the treatment of hypertension and heart failure.

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