Methyl 4-oxotetrahydro-2H-pyran-3-carboxylate Chemical Properties

Boiling point:

236.4±30.0 °C(Predicted)

Density 

1.201±0.06 g/cm3(Predicted)

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

pka

10.61±0.20(Predicted)

Appearance

Colorless to light yellow Liquid

InChI

InChI=1S/C7H10O4/c1-10-7(9)5-4-11-3-2-6(5)8/h5H,2-4H2,1H3

InChIKey

SOWMVLQIMWETEK-UHFFFAOYSA-N

SMILES

C1OCCC(=O)C1C(OC)=O

Methyl 4-oxotetrahydro-2H-pyran-3-carboxylate Usage And Synthesis

Uses

Methyl 4-oxotetrahydro-2H-pyran-3-carboxylate is a carboxylate derivative, and used as a pharmaceutical intermediate.

Synthesis

Methyl 4-oxotetrahydro-2H-pyran-3-carboxylate was synthesized by reacting tetrahydropyranone with dimethyl carbonate in the presence of TEA.

References

[1] Patent: WO2014/15291, 2014, A1. Location in patent: Page/Page column 183
[2] Patent: WO2016/210331, 2016, A1. Location in patent: Paragraph 0254; 0255
[3] Patent: WO2016/210330, 2016, A1. Location in patent: Paragraph 0520-0521
[4] Patent: WO2013/10092, 2013, A1. Location in patent: Page/Page column 26
[5] Patent: WO2013/12723, 2013, A1. Location in patent: Page/Page column 40

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