3,8,10-Trihydroxy-6-(2-methyl-1-propenyl)-6H,7H-[1]benzopyrano[4,3-b][1]benzopyran-7-one Chemical Properties

Boiling point:

628.2±55.0 °C(Predicted)

Density 

1.53±0.1 g/cm3(Predicted)

solubility 

Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.

form 

cryst.

pka

6.95±0.40(Predicted)

color 

Yellow

3,8,10-Trihydroxy-6-(2-methyl-1-propenyl)-6H,7H-[1]benzopyrano[4,3-b][1]benzopyran-7-one Usage And Synthesis

Uses

Cyclocommunol is a prenylflavonoid with antityrosinase and antiplatelet activitie, can be solated from breadfruit. Cyclocommunol exerts anti-tumor activity and inhibits the growth of human hepatoma and gastric cancer cells with IC50 values between 16 and 80 μM. Cyclocommunol shows proapoptotic effect on oral squamous cell carcinoma (OSCC)[1].

Definition

ChEBI: Cyclocommunol is an extended flavonoid.

target

PAFR

References

[1] Weng JR, et al. Cyclocommunol induces apoptosis in human oral squamous cell carcinoma partially through a Mcl-1-dependent mechanism. Phytomedicine. 2018 Jan 15;39:25-32. DOI:10.1016/j.phymed.2017.12.004

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