Micafungin FR-179642 impurity (acid) Chemical Properties

Melting point:

>150oC (dec.)

Density 

1.75±0.1 g/cm3 (20 ºC 760 Torr)

storage temp. 

Hygroscopic, -20°C Freezer, Under inert atmosphere

solubility 

DMSO (Slightly, Heated), Methanol (Slightly, Heated, Sonicated)

pka

-4.46±0.18(Predicted)

form 

Solid

color 

White to Off-White

Stability:

Hygroscopic

Micafungin FR-179642 impurity (acid) Usage And Synthesis

Uses

FR 179642 is an impurity of Micafungin (M342350), a lipopeptide compound that acts as an antifungal agent with activity against Aspergillus and Candida species.

Definition

Micafungin FR-179642 impurity (acid) is an impurity in micafungin that can be present as trace amounts in the final product and may contribute to hemolytic activity. This impurity is formed by hydrolysis during the synthesis process. Micafungin is an antifungal drug that inhibits the synthesis of ergosterol, a vital component of fungal cell membranes.

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