(3R,4R)-3-[(6-amino-4-pyrimidinyl)methylamino]-4-methyl-β-oxo-1-Piperidinepropanenitrile Chemical Properties

Melting point:

238 - 240°C

Boiling point:

551.0±50.0 °C(Predicted)

Density 

1.249±0.06 g/cm3(Predicted)

storage temp. 

Refrigerator

solubility 

Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)

pka

6.06±0.60(Predicted)

form 

Solid

color 

White to Off-White

(3R,4R)-3-[(6-amino-4-pyrimidinyl)methylamino]-4-methyl-β-oxo-1-Piperidinepropanenitrile Usage And Synthesis

Uses

Tofacitinib Citrate Impurity is derived from (3R,?4R)?-N,?4-?Dimethyl-?1-?benzyl?-3-?piperidinamine (D464895), which is a reagent used in the preparation of Janus tyrosine kinase inhibitors for the treatment of autoimmune diseases.

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