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XPhos Pd G3

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XPhos Pd G3 Basic information

Product Name:
XPhos Pd G3
Synonyms:
  • XPhos Pd G3
  • Methanesulfonato(2-dicyclohexylphosphino-2',4',6'-tri-i-propyl-1,1'-biphenyl)(2'-amino-1,1'-biphenyl-2-yl)palladium(II)
  • (2-Dicyclohexylphosphino-2′,4′,6′-triisopropyl-1,1′-biphenyl)[2-(2′-amino-1,1′-biphenyl)]palladium(II) methanesulfonate
  • Methanesulfonato(2-dicyclohexylphosphino-2',4',6'-tri-i-propyl-1,1'-biphenyl)(2'-aMino-1,1'-biphenyl-2-yl)palladiuM(II), Min. 98% [XPhos Palladacycle]
  • Methanesulfonato(2-dicyclohexylphosphino-2',4',6'-tri-i-propyl-1,1'-biphenyl)(2'-aMino-1,1'-biphenyl-2-yl)palladiuM(II), Min. 98%
  • XPhos G3
  • METHANESULFONATO(2-DICYCLOHEXYLPHOSPHINO-2',4',6'-TRI-I-PROPYL-1,1'-BIPHENYL)(2'-AMINO-1,1'-BIPHENYL-2-YL)PALLADIUM(II), MIN. 98
  • METHANESULFONATO(2-DICYCLOHEXYLPHOSPHINO-2',4',6'-TRI-I-PROPYL-1,1'-BIPHENYL)(2'-AMINO-1,1'-BIPHENYL-2-YL)PALLADIUM(II)DICHLOROMETHANEADDUCT(XPHOS Pd G3)
CAS:
1445085-55-1
MF:
C46H62NO3PPdS
MW:
846.46
Product Categories:
  • Buchwald Ligands&Precatalysts
  • Buchwald Precatalysts Series
  • Pd
Mol File:
1445085-55-1.mol
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XPhos Pd G3 Chemical Properties

Melting point:
146-151°C (decomposition)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
form 
Powder
color 
white to off-white
InChI
InChI=1S/C33H49P.C12H9N.CH4O3S.Pd/c1-23(2)26-21-30(24(3)4)33(31(22-26)25(5)6)29-19-13-14-20-32(29)34(27-15-9-7-10-16-27)28-17-11-8-12-18-28;13-12-9-5-4-8-11(12)10-6-2-1-3-7-10;1-5(2,3)4;/h13-14,19-25,27-28H,7-12,15-18H2,1-6H3;1-6,8-9,13H;1H3,(H,2,3,4);/q;-2;;+2
InChIKey
VXKANHUGMZCOIM-UHFFFAOYSA-N
SMILES
P(C1CCCCC1)(C1CCCCC1)(C1C=CC=CC=1C1C(=CC(C(C)C)=CC=1C(C)C)C(C)C)[Pd+2]1(NC2=CC=CC=C2C2=CC=CC=[C-]12)[O-]S(=O)(=O)C
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Safety Information

Risk Statements 
52/53
Safety Statements 
61
WGK Germany 
3
HS Code 
2843909000
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XPhos Pd G3 Usage And Synthesis

Reaction

Palladium precatalyst for facile C-N cross-coupling reactions.

Uses

XPhos Pd G3 may be used in the following reactions:

  • Cyanation reaction of heterocyclic halides.
  • Coupling of heteroaryl chlorides with polyfluoroaryl zinc reagents.
  • Coupling of 2,6-difluorophenylboronic acid with (hetero)aryl chlorides.

Uses

Convenient dosable form of XPhos-Pd-G3.
0.025 mmoles per capsule (1EA = 0.025 mmoles)

General Description

XPhos Pd G3 is a third generation (G3) Buchwald precatalyst. It is air, moisture and thermally-stable and is highly soluble in a wide range of common organic solvents. It has long life in solutions. XPhos Pd G3 is an excellent reagent for Suzuki cross-coupling reactions. Some of its unique features include lower catalyst loadings, shorter reaction time, efficient formation of the active catalytic species and accurate control of ligand: palladium ratio.

XPhos Pd G3Supplier

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