ChemicalBook > Product Catalog > Biochemical Engineering > Inhibitors > Cytoskeletal Signaling > HSP e.g. HSP90 inhibitors > CH5138303
CH5138303
CH5138303 Basic information
- Product Name:
- CH5138303
- Synonyms:
-
- CH5138303
- Butanamide, 4-[[4-amino-6-(5-chloro-1H,3H-naphtho[1,8-cd]pyran-6-yl)-1,3,5-triazin-2-yl]thio]-
- CH5138303_Hsp90
- 4-[(4-Amino-6-[7-chloro-3-oxatricyclo[7.3.1.0(5,13)] trideca-1(13),5,7,9,11-pentaen-8-yl]-1,3,5-triazin-2-yl)sulfanyl]butanamide
- 4-[[4-Amino-6-(5-chloro-1H,3H-naphtho[1,8-cd]pyran-6-yl)-1,3,5-triazin-2-yl]thio]butanamide
- 4-((4-Amino-6-(5-chloro-1,3-dihydrobenzo[de]isochromen-6-yl)-1,3,5-triazin-2-yl)thio)butanamid
- 4-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-1,3,5-triazin-2-ylsulfanyl]butanamide
- CH5138303 USP/EP/BP
- CAS:
- 959763-06-5
- MF:
- C19H18ClN5O2S
- MW:
- 415.9
- Product Categories:
-
- Inhibitors
- Mol File:
- 959763-06-5.mol
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CH5138303 Chemical Properties
- Boiling point:
- 813.1±75.0 °C(Predicted)
- Density
- 1.51±0.1 g/cm3(Predicted)
- storage temp.
- Desiccate at -20°C
- solubility
- insoluble in H2O; insoluble in EtOH; ≥19.95 mg/mL in DMSO
- form
- solid
- pka
- 16.39±0.40(Predicted)
- color
- White to off-white
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CH5138303 Usage And Synthesis
Description
CH5138303 is a triazine Hsp90 inhibitor. CH5138303 binds to the N-terminus of Hsp90α (Kd = 0.52 nM) and inhibits growth of HCT116 and NCI-N87 human tumor cell lines in vitro (IC50s = 89 and 66 nM, respectively). CH5138303 also inhibits growth of human NCI-N87 gastric cancer xenografts (ED50 = 3.9 mg/kg) and displays high oral bioavailability in mice.
target
Hsp90
References
[1]. suda a, kawasaki k, komiyama s, et al. design and synthesis of 2-amino-6-(1h,3h-benzo[de]isochromen-6-yl)-1,3,5-triazines as novel hsp90 inhibitors. bioorg med chem, 2014, 22(2): 892-905.
CH5138303Supplier
Shanghai Boyle Chemical Co., Ltd.
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- sales@boylechem.com
Guangzhou Isun Pharmaceutical Co., Ltd
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- 020-39119399 18927568969
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AdooQ BioScience, LLC
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- +1 (866) 930-6790
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Target molecule Corp.
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- 857-239-0968
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Amadis Chemical Company Limited
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- 571-89925085
- sales@amadischem.com