CAY10683 (SantacruzaMate A) Chemical Properties

Boiling point:

508.1±43.0 °C(Predicted)

Density 

1.087±0.06 g/cm3(Predicted)

storage temp. 

-20°

solubility 

Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 20 mg/ml).

form 

solid

pka

12.68±0.46(Predicted)

color 

Off-white

Stability:

Stable for 2 years from date of purchse as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.

CAY10683 (SantacruzaMate A) Usage And Synthesis

Description

Santacruzamate A (1477949-42-0) is a highly potent and selective inhibitor of HDAC2 isolated from the Panamanian marine cyanobacterium?cf. Symploca?(IC50=0.119 and 434 nM for HDAC2 and HDAC6 respectively).1?Induces apoptosis and cancer cell death only in combination with other HDAC1 inhibitors.2?Potential therapeutic agent for breast cancer.3?Attenuates Aβ fragment (Aβ25-35)-induced toxicity in PC12 cells by enhancing ER stress tolerance.4?Ameliorates Alzheimer’s disease-like pathology in mouse models.4

Uses

Santacruzamate A is a natural product isolated from Panamanian marine cyanobacterium Symploca sp; a histone deacetylases (HDACs) inhibitor; an attractive targeted therapy against breast cancer in women.

Definition

ChEBI: Santacruzamate A is an organooxygen compound and an organonitrogen compound. It is functionally related to a gamma-amino acid.

storage

Store at -20°C

References

1) Pavlik?et al.?(2013),?Santacruzamate A, a potent and selective histone deacetylase inhibitor from the Panamanian marine cyanobacterium cf. Symploca sp.; J. Nat. Prod.,?76?2026 2) Zhou?et al.?(2018),?Pharmacological or transcriptional inhibition of both HDAC1 and 2 leads to cell cycle blockage and apoptosis via p21Waf1/Cip1 and p19INK4d upregulation in hepatocellular carcinoma; Cell Prolif.,?51(3)?e12447 3) Damaskos?et al.?(2017),?Histone Deacetylase Inhibitors: An Attractive Therapeutic Strategy Against Breast Cancer;?Anticancer Res.,?37?35 4) Chen?et al.?(2019),?Santacruzamate A Ameliorates AD-Like Pathology by Enhancing ER Stress Tolerance Through Regulating the Functions of KDELR and Mia40-ALR in vivo and in vitro;?Front. Cell. Neurosci.,?13?61

CAY10683 (SantacruzaMate A)(1477949-42-0)Related Product Information

• DO264
• METHOPRENE ACID
• Dequalinium chloride
• Fruquintinib|HMPL-013
• Y27632 (hydrochloride)
• Axitinib
• PFI3
• VE 822
• Ruxolitinib
• Olaparib